publication . Other literature type . Article . 2009

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

Daniela Giustarini; Isabella Dalle-Donne;
  • Published: 06 Oct 2009
  • Publisher: Informa UK Limited
Oxidative stress has been related increasingly to the onset and/or progression of a growing number of human diseases. However, large studies on supplementation with anti-oxidants for prevention or treatment of different pathologies have yielded contradictory and mostly negative results, as documented by numerous meta-analyses and clinical trials. Here we analyze in detail the findings of these studies and discuss major aspects that, in our opinion, are likely to be responsible for these confounding data. With the belief that a clear correlation between disease and oxidative stress is far from being proven for most pathological conditions, our argument focuses on...
free text keywords: General Biochemistry, Genetics and Molecular Biology, Clinical Biochemistry, Biochemistry, medical
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