publication . Article . Other literature type . 2004

role of apoptosis in reperfusion injury

Eefting, F;
Open Access
  • Published: 15 Feb 2004 Journal: Cardiovascular Research, volume 61, pages 414-426 (issn: 0008-6363, Copyright policy)
  • Publisher: Oxford University Press (OUP)
Many changes occur during reperfusion of the myocardium after ischemic damage. Necrosis and apoptosis appear to be ongoing during ischemia, while apoptosis is boosted by the reperfusion event. In the past 10 years, distinct intracellular pathways important for hypertrophy, apoptosis, cardiac failure, ischemic preconditioning and reperfusion damage have been recognized. The eventual response of the cardiomyocyte will depend on energy and time available as well as changes in pH and ion handling and the delicate balance of activation of signaling molecules and transcription factors. There is agreement on the central role of mitochondria and nitric oxide (NO) in pro...
free text keywords: Ischemic preconditioning, Reperfusion injury, medicine.disease, medicine, Ischemia, Necrosis, medicine.symptom, Programmed cell death, Cardiology, medicine.medical_specialty, Pharmacology, Apoptosis, Reperfusion therapy, business.industry, business, Internal medicine, Immunology, Cardioprotection
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