publication . Article . 2013

Cognitive changes predict functional decline in ALS A population-based longitudinal study

Elamin, M.; Bede, P.; Byrne, S.; Jordan, N.; Gallagher, L.; Wynne, B.; O'Brien, C.; Phukan, J.; Lynch, C.; Pender, N.; ...
Closed Access English
  • Published: 03 Apr 2013 Journal: NEUROLOGY (issn: 0028-3878, Copyright policy)
  • Publisher: LIPPINCOTT WILLIAMS & WILKINS
Abstract
Objective: To determine whether cognitive status in patients with amyotrophic lateral sclerosis (ALS) is a useful predictor of attrition and motor and cognitive decline. Methods: Cognitive testing was undertaken in a large population-based cohort of incident ALS patients using a longitudinal, case-control study design. Normative data for neuropsychological tests were generated using age-, sex-, and education-matched healthy controls who also underwent repeated assessments. Data were analyzed to generate models for progression/spread. Results: One hundred eighty-six patients with ALS who had no evidence of C9orf72 hexanucleotide repeat expansion were enrolled. A ...
Subjects
free text keywords: Clinical Neurology, Longitudinal study, Neuropsychology, Amyotrophic lateral sclerosis, medicine.disease, medicine, Cohort, Cognition, business.industry, business, Population, education.field_of_study, education, Physical therapy, medicine.medical_specialty, Cognitive test, Physical medicine and rehabilitation, Cognitive decline
Funded by
EC| EURO-MOTOR
Project
EURO-MOTOR
European multidisciplinary ALS network identification to cure motor neuron degeneration
  • Funder: European Commission (EC)
  • Project Code: 259867
  • Funding stream: FP7 | SP1 | HEALTH
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