publication . Article . Other literature type . 2006

Pannexin 1 in erythrocytes: Function without a gap

Silviu Locovei; Gerhard Dahl; Li Bao;
Open Access
  • Published: 08 May 2006 Journal: Proceedings of the National Academy of Sciences, volume 103, pages 7,655-7,659 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions. Yet, here we show with immunohistochemical and electrophysiological data that erythrocytes express the gap junction protein pannexin 1. This protein, in addition to forming gap junction channels in paired oocytes, can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Consistent w...
Persistent Identifiers
Subjects
free text keywords: Multidisciplinary, Biological Sciences, Vesicle, Patch clamp, Adenosine triphosphate, chemistry.chemical_compound, chemistry, Cell biology, Gap junction, Carbenoxolone, medicine.drug, medicine, Biology, Pannexin, Ion channel, Mechanosensitive channels
Abstract
ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions. Yet, here we show with immunohistochemical and electrophysiological data that erythrocytes express the gap junction protein pannexin 1. This protein, in addition to forming gap junction channels in paired oocytes, can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Consistent w...
Persistent Identifiers
Subjects
free text keywords: Multidisciplinary, Biological Sciences, Vesicle, Patch clamp, Adenosine triphosphate, chemistry.chemical_compound, chemistry, Cell biology, Gap junction, Carbenoxolone, medicine.drug, medicine, Biology, Pannexin, Ion channel, Mechanosensitive channels
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