publication . Article . Other literature type . 2016

causes of evolutionary rate variation among protein sites

Echave, Julian; Spielman, Stephanie J.; Wilke, Claus O.;
Open Access
  • Published: 19 Jan 2016 Journal: Nature Reviews Genetics, volume 17, pages 109-121 (issn: 1471-0056, eissn: 1471-0064, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
It has long been recognized that certain sites within a protein, such as sites in the protein core or catalytic residues in enzymes, are more conserved than are other sites. However, our understanding of rate variation among sites remains surprisingly limited. Recent progress to address this includes the development of a wide array of reliable methods to estimate site-specific substitution rates from sequence alignments. In addition, several molecular traits have been identified that correlate with site-specific rates, and novel mechanistic, biophysical models have been proposed to explain the observed correlations. Nonetheless, at best, current models explain a...
Subjects
free text keywords: Computational biophysics, Biology, Bioinformatics, Molecular biophysics, Computational model, Molecular evolution, Rate of evolution, Evolutionary theory, Article
Related Organizations
Abstract
It has long been recognized that certain sites within a protein, such as sites in the protein core or catalytic residues in enzymes, are more conserved than are other sites. However, our understanding of rate variation among sites remains surprisingly limited. Recent progress to address this includes the development of a wide array of reliable methods to estimate site-specific substitution rates from sequence alignments. In addition, several molecular traits have been identified that correlate with site-specific rates, and novel mechanistic, biophysical models have been proposed to explain the observed correlations. Nonetheless, at best, current models explain a...
Subjects
free text keywords: Computational biophysics, Biology, Bioinformatics, Molecular biophysics, Computational model, Molecular evolution, Rate of evolution, Evolutionary theory, Article
Related Organizations
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publication . Article . Other literature type . 2016

causes of evolutionary rate variation among protein sites

Echave, Julian; Spielman, Stephanie J.; Wilke, Claus O.;