publication . Article . Other literature type . 2010

Kisspeptins: Bridging energy homeostasis and reproduction

Castellano, Juan M.; Bentsen, Agnete H.; Mikkelsen, Jens D.; Tena-Sempere, Manuel;
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  • Published: 01 Dec 2010 Journal: Brain Research, volume 1,364, pages 129-138 (issn: 0006-8993, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive disorders. The mechanisms for such a close connection between energy balance and reproduction have been the subject of considerable attention; however, our understanding of the neurobiological basis for this phenomenon is still incomplete. In mid 1990s, the adipose-hormone, leptin, was proven as an essential signal for transmitting metabolic information onto the centers governing puberty and reproduction; yet, the ultimate mode of action of le...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
free text keywords: Developmental Biology, General Neuroscience, Molecular Biology, Clinical Neurology, Kisspeptin, Endocrinology, medicine.medical_specialty, medicine, Ghrelin, Energy homeostasis, Leptin, Adipokine, KISS1 Gene, PI3K/AKT/mTOR pathway, Internal medicine, Biology, Kisspeptins
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publication . Article . Other literature type . 2010

Kisspeptins: Bridging energy homeostasis and reproduction

Castellano, Juan M.; Bentsen, Agnete H.; Mikkelsen, Jens D.; Tena-Sempere, Manuel;