publication . Article . Other literature type . 2014

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma

Carsten Linnemann; Arno Velds; Sjoerd H. van der Burg; Jorg J A Calis; Laura Bies; Els M. E. Verdegaal; Ton N. M. Schumacher; Sam Behjati; Henk Hilkmann; Marten Visser; ...
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  • Published: 22 Dec 2014
Abstract
Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, Cancer immunotherapy, medicine.medical_treatment, medicine, Melanoma, medicine.disease, Cancer, Biology, Immunology, Mutation, medicine.disease_cause, Epitope, Antigen, Immunotherapy, CD8
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http://dx.doi.org/10.1038/nm.3...
Other literature type . 2014
Provider: Datacite
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Article . 2015
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Nature Medicine
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