publication . Article . Other literature type . 2014

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma

Name: High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma
Keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine

Carsten Linnemann; Arno Velds; Sjoerd H. van der Burg; Jorg J A Calis; Laura Bies; Els M. E. Verdegaal; Ton N. M. Schumacher; Sam Behjati; Henk Hilkmann; Marten Visser; ...

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Published: 22 Dec 2014

Summary

Abstract

Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma

doi: 10.1038/nm.3773

handle: 1887/104360

Subjects

free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, Cancer immunotherapy, medicine.medical_treatment, medicine, Melanoma, medicine.disease, Cancer, Biology, Immunology, Mutation, medicine.disease_cause, Epitope, Antigen, Immunotherapy, CD8

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