publication . Article . Other literature type . 2014

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease

Jiang Teng; Tan Lan; Zhu Xi-Chen; Zhang Qiao-Quan; Cao Lei; Tan Meng-Shan; Gu Li-Ze; Wang Hui-Fu; Ding Zheng-Zheng; Zhang Ying-Dong; ...
Open Access
  • Published: 22 Jul 2014 Journal: Neuropsychopharmacology, volume 39, pages 2,949-2,962 (issn: 0893-133X, eissn: 1740-634X, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer's disease (AD), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an APOE ɛ4 allele. To date, the expression and biologic functions of TREM2 under AD context remain largely unknown. Using APPswe/PS1dE9 mice, a transgenic model of AD, we showed that TREM2 was upregulated in microglia during disease progression. For the first time, we provided in vitro and in vivo evidence that this upregulation was attributed to the increased amyloid-β (Aβ)1–42 levels in the brain. By knockdown and overexpress...
Subjects
free text keywords: Pharmacology, Psychiatry and Mental health, Psychology, Microglia, medicine.anatomical_structure, medicine, TREM2, Genetically modified mouse, Neuropathology, Presenilin, Downregulation and upregulation, Neuroscience, Schizophrenia, medicine.disease, Immunology, Alzheimer's disease, Original Article
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