publication . Other literature type . Article . 2000

The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions.

M. Lipsitch; C. T. Bergstrom; B. R. Levin;
Open Access English
  • Published: 15 Feb 2000
  • Publisher: The National Academy of Sciences
Abstract
A simple mathematical model of bacterial transmission within a hospital was used to study the effects of measures to control nosocomial transmission of bacteria and reduce antimicrobial resistance in nosocomial pathogens. The model predicts that: (i) Use of an antibiotic for which resistance is not yet present in a hospital will be positively associated at the individual level (odds ratio) with carriage of bacteria resistant to other antibiotics, but negatively associated at the population level (prevalence). Thus inferences from individual risk factors can yield misleading conclusions about the effect of antibiotic use on resistance to another antibiotic. (ii) ...
Subjects
free text keywords: Biological Sciences, Carriage, Biotechnology, business.industry, business, Epidemiology, medicine.medical_specialty, medicine, Intensive care medicine, Antibiotics, medicine.drug_class, Antibiotic resistance, Odds ratio, Infection control, Population, education.field_of_study, education, Biology, Drug resistance
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