publication . Other literature type . Article . 2015

Genetic studies of body mass index yield new insights for obesity biology

Francesco CUCCA;
  • Published: 12 Feb 2015
  • Publisher: Springer Science and Business Media LLC
Abstract
<p>Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P &lt;5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts ...
Subjects
free text keywords: Clinical Medicine, Klinisk medicin, Institute of Physiology, 570 Life sciences; biology, 610 Medicine & health, Body Mass Index; Genome-Wide Association Study; Obesity/genetics; Obesity/metabolism, body mass index (BMI), obesity, genetic basis, GENOME-WIDE ASSOCIATION, PROVIDES INSIGHTS, GLYCEMIC TRAITS, HUMAN HEIGHT, LOCI, METAANALYSIS, VARIANTS, EXPRESSION, PATHWAYS, ARCHITECTURE, Adipogenesis; Adiposity; Age Factors; Continental Population Groups; Energy Metabolism; Europe; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Insulin; Male; Obesity; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Synapses; Body Mass Index; Genome-Wide Association Study; Multidisciplinary, Article
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publication . Other literature type . Article . 2015

Genetic studies of body mass index yield new insights for obesity biology

Francesco CUCCA;