publication . Preprint . 2017

Shared Genetic Architecture Of Asthma With Allergic Diseases: A Genome-wide Cross Trait Analysis Of 112,000 Individuals From UK Biobank

Zhu, Zhaozhong; Lee, Phil H.; Chaffin, Mark D.; Chung, Wonil; Loh, Po-Ru; Lu, Quan; Christiani, David C.; Liang, Liming;
Open Access
  • Published: 26 May 2017
  • Publisher: Cold Spring Harbor Laboratory
Abstract
<jats:title>Abstract</jats:title><jats:p>Clinical and epidemiological data suggest that asthma and allergic diseases are associated. And may share a common genetic etiology. We analyzed genome-wide single-nucleotide polymorphism (SNP) data for asthma and allergic diseases in 35,783 cases and 76,768 controls of European ancestry from the UK Biobank. Two publicly available independent genome wide association studies (GWAS) were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (<jats:italic>r<jats:sub>g</jats:sub></jats:italic> = 0.75, <jats:italic>P</jats:italic> = 6.84×10<jats:sup>−62</jats:sup>). C...
Subjects
free text keywords: Genome-wide association study, Allergy, medicine.disease, medicine, Genetics, Genetic architecture, Biology, Asthma, Immunology, Biobank, Genome, Locus (genetics), SNP
84 references, page 1 of 6

Lenz, H.J. Management and preparedness for infusion and hypersensitivity reactions. Oncologist 12, 601-9 (2007).

Wallace, D.V. et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122, S1-84 (2008).

Torgerson, D.G. et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 43, 887-92 (2011).

Moffatt, M.F. et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363, 1211-21 (2010). [OpenAIRE]

BMC Med Genomics 7, 48 (2014).

Ramasamy, A. et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol 128, 996-1005 (2011).

Pillai, S.G. et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 5, e1000421 (2009).

Leynaert, B., Neukirch, F., Demoly, P. & Bousquet, J. Epidemiologic evidence for asthma and rhinitis comorbidity. J Allergy Clin Immunol 106, S201-5 (2000). [OpenAIRE]

Brauer, M. et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med 166, 1092-8 (2002).

Pharmacoeconomics 12, 585-95 (1997).

Liang, L. et al. An epigenome-wide association study of total serum immunoglobulin E concentration. Nature 520, 670-4 (2015).

Cotsapas, C. et al. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet 7, e1002254 (2011). [OpenAIRE]

Criswell, L.A. et al. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

Am J Hum Genet 76, 561-71 (2005).

Cross-Disorder Group of the Psychiatric Genomics, C. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371-9 (2013).

84 references, page 1 of 6
Abstract
<jats:title>Abstract</jats:title><jats:p>Clinical and epidemiological data suggest that asthma and allergic diseases are associated. And may share a common genetic etiology. We analyzed genome-wide single-nucleotide polymorphism (SNP) data for asthma and allergic diseases in 35,783 cases and 76,768 controls of European ancestry from the UK Biobank. Two publicly available independent genome wide association studies (GWAS) were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (<jats:italic>r<jats:sub>g</jats:sub></jats:italic> = 0.75, <jats:italic>P</jats:italic> = 6.84×10<jats:sup>−62</jats:sup>). C...
Subjects
free text keywords: Genome-wide association study, Allergy, medicine.disease, medicine, Genetics, Genetic architecture, Biology, Asthma, Immunology, Biobank, Genome, Locus (genetics), SNP
84 references, page 1 of 6

Lenz, H.J. Management and preparedness for infusion and hypersensitivity reactions. Oncologist 12, 601-9 (2007).

Wallace, D.V. et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122, S1-84 (2008).

Torgerson, D.G. et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 43, 887-92 (2011).

Moffatt, M.F. et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363, 1211-21 (2010). [OpenAIRE]

BMC Med Genomics 7, 48 (2014).

Ramasamy, A. et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol 128, 996-1005 (2011).

Pillai, S.G. et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 5, e1000421 (2009).

Leynaert, B., Neukirch, F., Demoly, P. & Bousquet, J. Epidemiologic evidence for asthma and rhinitis comorbidity. J Allergy Clin Immunol 106, S201-5 (2000). [OpenAIRE]

Brauer, M. et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med 166, 1092-8 (2002).

Pharmacoeconomics 12, 585-95 (1997).

Liang, L. et al. An epigenome-wide association study of total serum immunoglobulin E concentration. Nature 520, 670-4 (2015).

Cotsapas, C. et al. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet 7, e1002254 (2011). [OpenAIRE]

Criswell, L.A. et al. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

Am J Hum Genet 76, 561-71 (2005).

Cross-Disorder Group of the Psychiatric Genomics, C. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371-9 (2013).

84 references, page 1 of 6
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