publication . Other literature type . Article . 2015

Screening, verification, and optimization of biomarkers for early prediction of cardiotoxicity based on metabolomics.

Yubo Li; Liang Ju; Zhiguo Hou; Haoyue Deng; Zhenzhu Zhang; Lei Wang; Zhen Yang; Jia Yin; Yanjun Zhang;
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  • Published: 18 May 2015
  • Publisher: American Chemical Society (ACS)
Abstract
Drug-induced cardiotoxicity seriously affects human health and drug development. However, many conventional detection indicators of cardiotoxicity exhibit significant changes only after the occurrence of severe heart injuries. Therefore, we investigated more sensitive and reliable indicators for the evaluation and prediction of cardiotoxicity. We created rat cardiotoxicity models in which the toxicity was caused by doxorubicin (20 mg/kg), isoproterenol (5 mg/kg), and 5-fluorouracil (125 mg/kg). We collected data from rat plasma samples based on metabolomics using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Following multi...
Subjects
free text keywords: Biochemistry, General Chemistry
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