publication . Article . Other literature type . 2001

Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials.

Christine E. Schmidt; Arundhati Kotwal;
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  • Published: 01 May 2001 Journal: Biomaterials, volume 22, pages 1,055-1,064 (issn: 0142-9612, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Electrical charges have been shown to enhance nerve regeneration; however, the mechanisms for this effect are unclear. One hypothesis is that an electrical stimulus alters the local electrical fields of extracellular matrix molecules, changing protein adsorption. We have investigated this hypothesis--that electrical stimulation increases the adsorption of serum proteins, specifically fibronectin (FN), to the electrically conducting polymer polypyrrole (PP), thereby, increasing neurite extension. PP was used because electrical stimulation of PP has been shown to significantly enhance neurite outgrowth, and more importantly, PP can be formed into conduits to guide...
Subjects
free text keywords: Biophysics, Mechanics of Materials, Bioengineering, Biomaterials, Ceramics and Composites, Tissue engineering, Protein adsorption, Stimulation, Anatomy, Peripheral nervous system, medicine.anatomical_structure, medicine, Adsorption, Neuron, Materials science, Neurite, Fibronectin, biology.protein, biology
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