publication . Other literature type . Article . 2014

Methods for Adjusting for Bias Due to Crossover in Oncology Trials

Sandrine Faivre; Juan Valle;
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  • Published: 05 Mar 2014
  • Publisher: Springer Science and Business Media LLC
Abstract
Trials of new oncology treatments often involve a crossover element in their design that allows patients receiving the control treatment to crossover to receive the experimental treatment at disease progression or when sufficient evidence about the efficacy of the new treatment is achieved. Crossover leads to contamination of the initial randomized groups due to a mixing of the effects of the control and experimental treatments in the reference group. This is further complicated by the fact that crossover is often a very selective process whereby patients who switch treatment have a different prognosis than those who do not. Standard statistical techniques, incl...
Subjects
free text keywords: Public Health, Environmental and Occupational Health, Health Policy, Pharmacology
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