publication . Review . Article . 2015

Bridging the gap between statistical and biological epistasis in Alzheimer's disease.

Ebbert, Mark T. W.; Ridge, Perry G.; Kauwe, John S. K.;
Open Access English
  • Published: 01 May 2015 Journal: BioMed Research International (issn: 2314-6133, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
<jats:p>Alzheimer’s disease affects millions of people worldwide and incidence is expected to rise as the population ages, but no effective therapies exist despite decades of research and more than 20 known disease markers. Research has shown that Alzheimer’s disease’s missing heritability remains extensive with an estimated 25% of phenotypic variance unexplained by known variants. The missing heritability may be explained by missing variants or by epistasis. Researchers often focus on individual loci rather than epistatic interactions, which is likely an oversimplification of the underlying biology since most phenotypes are affected by multiple genes. Focusing ...
Subjects
free text keywords: Article Subject, Medicine, R, Review Article, Locus (genetics), Disease, Biology, Epistasis, Evolutionary biology, Alzheimer's disease, medicine.disease, Disease markers, Biochemistry, Genetics, Missing heritability problem, Population, education.field_of_study, education, Bridging (networking)
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