publication . Article . Other literature type . 1972

The Evolutionary Development of Modifier Genes

Karlin, Samuel; Mcgregor, James;
Open Access
  • Published: 01 Dec 1972 Journal: Proceedings of the National Academy of Sciences, volume 69, pages 3,611-3,614 (issn: 0027-8424, eissn: 1091-6490, Copyright policy)
  • Publisher: Proceedings of the National Academy of Sciences
Abstract
Abstract The main findings of a study of the evolution of modifier gene frequencies in models of deterministic population genetics are presented. A wide variety of random mating systems are subject to selection with modifiers operating, in different cases, on mutation rates, dominance, migration between subpopulations, and linkage between other loci. In all these instances the modifier frequencies evolve in such a way as to maximize the mean fitness of the population at equilibrium. This is remarkable since, except for the dominance modifier, the modifier genes are selectively neutral in the sense that they do not affect the fitness of their individual carriers....
Subjects
free text keywords: Multidisciplinary, Biological Sciences: Genetics
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