publication . Other literature type . Article . 2005

A haplotype map of the human genome

Daniel Richter;
Open Access English
  • Published: 01 Oct 2005
Abstract
Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted. These data document the generality of recombination hotspots, a block-like structure of linkage disequilibrium and low haplotype diversity, leading to substantial correlations of SNPs with many of their neighbour...
Subjects
free text keywords: Article, Haplotypes - genetics, Genome, Human, Chromosomes, Human, Y - genetics, DNA, Mitochondrial - genetics, Polymorphism, Single Nucleotide - genetics, Genetics, Physiology, Haplotype, Evolutionary biology, Human genome, Biology
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Europe PubMed Central
Other literature type . 2005
http://dx.doi.org/10.1038/natu...
Other literature type . 2005
Provider: Datacite
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