publication . Other literature type . Article . 1987

Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans: a pharmacogenetic approach.

Al-Waiz, M.; Ayesh, R.; Mitchell, S. C.; Jeff Idle; Smith, R. L.;
  • Published: 01 Dec 1987
  • Publisher: Springer Science and Business Media LLC
Trimethylamine N-oxide (TMAO), which is naturally occurring in dietary marine fish, is well absorbed and excreted apparently unchanged as judged by end-product analysis. Such observations may conceal the fact that the amine N-oxide has undergone a sequence of deoxygenation and oxygenation reactions only to revert to the parental form and be excreted as such—a process that we propose to call metabolic retroversion. To evaluate this phenomenon for TMAO we have investigated the fate of the orally administered substance in healthy volunteers and in four subjects previously phenotyped as having an inherited deficiency with respect to the metabolic N-oxidation of trim...
free text keywords: Pharmacology (medical), Pharmacology
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