publication . Other literature type . Article . 1984

Biological activities of Eikenella corrodens outer membrane and lipopolysaccharide.

A Progulske; R Mishell; C Trummel; S C Holt;
Open Access English
  • Published: 01 Jan 1984
Abstract
Highly purified preparations of the outer membrane and lipopolysaccharide (LPS) of Eikenella corrodens strain ATCC 23834 and the outer membrane fraction (OMF) of strain 470 were tested in in vitro biological assays. The OMFs of both strains were found to be mitogenic for BDF and C3H/HeJ murine splenocytes. The E. corrodens LPS was mitogenic for BDF spleen cells; however, doses of LPS as high as 50 micrograms/ml failed to stimulate C3H/HeJ cells. When incubated with T-lymphocyte-depleted C3H/HeJ splenocytes, the strain 23834 OMF demonstrated significant mitogenic activity, indicating that the OMF is a B-cell mitogen by a mechanism other than that elicited by conv...
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Research Article, Immunology, Microbiology, Parasitology, Infectious Diseases, In vivo, Lipopolysaccharide, chemistry.chemical_compound, chemistry, Eikenella corrodens, biology.organism_classification, biology, Amebocyte, In vitro, Bacterial outer membrane, Limulus, Splenocyte
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publication . Other literature type . Article . 1984

Biological activities of Eikenella corrodens outer membrane and lipopolysaccharide.

A Progulske; R Mishell; C Trummel; S C Holt;