publication . Article . 2006

RNA Polymerase Promotes Splicing, Prevents Degradation

Martin J Hicks; Klemens Hertel;
Open Access English
  • Published: 01 Jun 2006 Journal: PLoS Biology, volume 4, issue 6 (issn: 1544-9173, eissn: 1545-7885, Copyright policy)
  • Publisher: Public Library of Science
  • Country: Algeria
Abstract
A novel in vitro method to study transcription and splicing leads to the proposal that linking transcription by Pol II and pre-mRNA splicing guarantees an extended half-life and proper processing of nascent pre-mRNAs.
Subjects
free text keywords: Life Sciences, carboxyl-terminal domain, polymerase-ii, capping enzyme, site selection, in-vivo, complex, elongation, mechanisms, initiation, binding, Research Article, Bioinformatics/Computational Biology, Biochemistry, In Vitro, Biology (General), QH301-705.5, General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Neuroscience, General Agricultural and Biological Sciences
Funded by
NIH| Mechanisms of Enhancer Dependent Splice Site Activation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R01GM062287-10
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Biomedical Informatics Training Program
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T15LM007443-07
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
52 references, page 1 of 4

Black, DL. Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem. 2003; 72: 291-336 [OpenAIRE] [PubMed]

Black, DL. Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology. Cell. 2000; 103: 367-370 [PubMed]

Graveley, BR. Alternative splicing: Increasing diversity in the proteomic world. Trends Genet. 2001; 17: 100-107 [OpenAIRE] [PubMed]

Maniatis, T, Tasic, B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature. 2002; 418: 236-243 [OpenAIRE] [PubMed]

Cramer, P, Pesce, CG, Baralle, FE, Kornblihtt, AR. Functional association between promoter structure and transcript alternative splicing. Proc Natl Acad Sci U S A. 1997; 94: 11456-11460 [OpenAIRE] [PubMed]

Auboeuf, D, Honig, A, Berget, SM, O'Malley, BW. Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science. 2002; 298: 416-419 [OpenAIRE] [PubMed]

Kornblihtt, AR, de la Mata, M, Fededa, JP, Munoz, MJ, Nogues, G. Multiple links between transcription and splicing. RNA. 2004; 10: 1489-1498 [OpenAIRE] [PubMed]

Fededa, JP, Petrillo, E, Gelfand, MS, Neverov, AD, Kadener, S. A polar mechanism coordinates different regions of alternative splicing within a single gene. Mol Cell. 2005; 19: 393-404 [OpenAIRE] [PubMed]

Maniatis, T, Reed, R. An extensive network of coupling among gene expression machines. Nature. 2002; 416: 499-506 [OpenAIRE] [PubMed]

Proudfoot, NJ, Furger, A, Dye, MJ. Integrating mRNA processing with transcription. Cell. 2002; 108: 501-512 [OpenAIRE] [PubMed]

Neugebauer, KM. On the importance of being co-transcriptional. J Cell Sci. 2002; 115: 3865-3871 [PubMed]

Bentley, D. The mRNA assembly line: Transcription and processing machines in the same factory. Curr Opin Cell Biol. 2002; 14: 336-342 [PubMed]

McCracken, S, Fong, N, Yankulov, K, Ballantyne, S, Pan, G. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature. 1997; 385: 357-361 [OpenAIRE] [PubMed]

McCracken, S, Fong, N, Rosonina, E, Yankulov, K, Brothers, G. 5′-capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997; 11: 3306-3318 [OpenAIRE] [PubMed]

Cho, EJ, Rodriguez, CR, Takagi, T, Buratowski, S. Allosteric interactions between capping enzyme subunits and the RNA polymerase II carboxy-terminal domain. Genes Dev. 1998; 12: 3482-2487 [OpenAIRE] [PubMed]

52 references, page 1 of 4
Abstract
A novel in vitro method to study transcription and splicing leads to the proposal that linking transcription by Pol II and pre-mRNA splicing guarantees an extended half-life and proper processing of nascent pre-mRNAs.
Subjects
free text keywords: Life Sciences, carboxyl-terminal domain, polymerase-ii, capping enzyme, site selection, in-vivo, complex, elongation, mechanisms, initiation, binding, Research Article, Bioinformatics/Computational Biology, Biochemistry, In Vitro, Biology (General), QH301-705.5, General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Neuroscience, General Agricultural and Biological Sciences
Funded by
NIH| Mechanisms of Enhancer Dependent Splice Site Activation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2R01GM062287-10
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Biomedical Informatics Training Program
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T15LM007443-07
  • Funding stream: NATIONAL LIBRARY OF MEDICINE
52 references, page 1 of 4

Black, DL. Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem. 2003; 72: 291-336 [OpenAIRE] [PubMed]

Black, DL. Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology. Cell. 2000; 103: 367-370 [PubMed]

Graveley, BR. Alternative splicing: Increasing diversity in the proteomic world. Trends Genet. 2001; 17: 100-107 [OpenAIRE] [PubMed]

Maniatis, T, Tasic, B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature. 2002; 418: 236-243 [OpenAIRE] [PubMed]

Cramer, P, Pesce, CG, Baralle, FE, Kornblihtt, AR. Functional association between promoter structure and transcript alternative splicing. Proc Natl Acad Sci U S A. 1997; 94: 11456-11460 [OpenAIRE] [PubMed]

Auboeuf, D, Honig, A, Berget, SM, O'Malley, BW. Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science. 2002; 298: 416-419 [OpenAIRE] [PubMed]

Kornblihtt, AR, de la Mata, M, Fededa, JP, Munoz, MJ, Nogues, G. Multiple links between transcription and splicing. RNA. 2004; 10: 1489-1498 [OpenAIRE] [PubMed]

Fededa, JP, Petrillo, E, Gelfand, MS, Neverov, AD, Kadener, S. A polar mechanism coordinates different regions of alternative splicing within a single gene. Mol Cell. 2005; 19: 393-404 [OpenAIRE] [PubMed]

Maniatis, T, Reed, R. An extensive network of coupling among gene expression machines. Nature. 2002; 416: 499-506 [OpenAIRE] [PubMed]

Proudfoot, NJ, Furger, A, Dye, MJ. Integrating mRNA processing with transcription. Cell. 2002; 108: 501-512 [OpenAIRE] [PubMed]

Neugebauer, KM. On the importance of being co-transcriptional. J Cell Sci. 2002; 115: 3865-3871 [PubMed]

Bentley, D. The mRNA assembly line: Transcription and processing machines in the same factory. Curr Opin Cell Biol. 2002; 14: 336-342 [PubMed]

McCracken, S, Fong, N, Yankulov, K, Ballantyne, S, Pan, G. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature. 1997; 385: 357-361 [OpenAIRE] [PubMed]

McCracken, S, Fong, N, Rosonina, E, Yankulov, K, Brothers, G. 5′-capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997; 11: 3306-3318 [OpenAIRE] [PubMed]

Cho, EJ, Rodriguez, CR, Takagi, T, Buratowski, S. Allosteric interactions between capping enzyme subunits and the RNA polymerase II carboxy-terminal domain. Genes Dev. 1998; 12: 3482-2487 [OpenAIRE] [PubMed]

52 references, page 1 of 4
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