publication . Other literature type . Article . 2003

Site-specific selfish genes as tools for the control and genetic engineering of natural populations

Burt, Austin;
  • Published: 07 May 2003
  • Publisher: The Royal Society
Abstract
Site-specific selfish genes exploit host functions to copy themselves into a defined target DNA sequence, and include homing endonuclease genes, group II introns and some LINE-like transposable elements. If such genes can be engineered to target new host sequences, then they can be used to manipulate natural populations, even if the number of individuals released is a small fraction of the entire population. For example, a genetic load sufficient to eradicate a population can be imposed in fewer than 20 generations, if the target is an essential host gene, the knockout is recessive and the selfish gene has an appropriate promoter. There will be selection for res...
Subjects
free text keywords: Selfish Genes, Genetics, Gene drive, Homing endonuclease, biology.protein, biology, Gene conversion, Gene, Genetic load, Gene Drive Technology, Population, education.field_of_study, education, Research Article
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