publication . Other literature type . Article . 2015

Mitochondrial pyruvate transport: a historical perspective and future research directions

Kyle S. McCommis; Brian N. Finck;
  • Published: 06 Mar 2015
  • Publisher: Portland Press Ltd.
Abstract
<jats:p>Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely on a membrane transport system to shuttle pyruvate across the impermeable inner mitochondrial membrane (IMM). Despite long-standing acceptance that transport of pyruvate into the mitochondrial matrix by a carrier-mediated process is required for the bulk of its metabolism, it has taken almost 40 years to determine the molecular identity of an IMM pyruvate carrier. Our current ...
Subjects
free text keywords: Article, Cell Biology, Biochemistry, Molecular Biology, Citric acid cycle, Pyruvate dehydrogenase complex, Dihydrolipoyl transacetylase, Mitochondrial matrix, Pyruvate decarboxylation, Gluconeogenesis, Pyruvate transport, Mitochondrial pyruvate transport, Biology
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publication . Other literature type . Article . 2015

Mitochondrial pyruvate transport: a historical perspective and future research directions

Kyle S. McCommis; Brian N. Finck;