publication . Article . Other literature type . 2012

Simultaneous segmentation and grading of anatomical structures for patient's classification: application to Alzheimer's disease.

Simon Eskildsen; Vladimir Fonov; Pierrick Coupe; D. Louis Collins;
Open Access English
  • Published: 15 Feb 2012
  • Publisher: Elsevier
  • Country: Spain
Data used in the preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database ( In this paper, we propose an innovative approach to robustly and accurately detect Alzheimer's disease (AD) based on the distinction of specific atrophic patterns of anatomical structures such as hippocampus (HC) and entorhinal cortex (EC). The proposed method simultaneously performs segmentation and grading of structures to efficiently capture the anatomical alterations caused by AD. Known as SNIPE (Scoring by Non-local Image Patch Estimator), the novel proposed grading measure is based on a nonlocal patch-bas...
free text keywords: Hippocampus, Hippocampus volume, Hippocampus grading, Patient's classification, Nonlocal means estimator, Alzheimer's disease, Entorhinal cortex, FISICA APLICADA, Alzheimer Disease, Humans, Magnetic Resonance Imaging, Time Factors, medial temporal lobe, Aging, detection, segmentation, grading, brain, neuroimaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Cognitive Neuroscience, Neurology
Related Organizations
Funded by
  • Funder: Canadian Institutes of Health Research (CIHR)
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