publication . Other literature type . Article . 2011

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.

John Cryan; Timothy Dinan;
Open Access English
  • Published: 29 Aug 2011
  • Publisher: National Academy of Sciences
  • Country: United Kingdom
Abstract
There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that chronic treatm...
Subjects
Medical Subject Headings: nervous system
free text keywords: Biological Sciences
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