publication . Article . Other literature type . 2008

Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling

Li, Guangnan; Kataoka, Hiroshi; Coughlin, Shaun R.; Pleasure, Samuel J.;
Open Access
  • Published: 22 Dec 2008 Journal: Development, volume 136, pages 327-335 (issn: 0950-1991, eissn: 1477-9129, Copyright policy)
  • Publisher: The Company of Biologists
Abstract
One striking feature of dentate gyrus development, distinct from the other cortical structures, is the relocation of neural precursors from the ventricular zone to the forming dentate pole to produce a lifelong neurogenic subgranular zone (SGZ). In this study, we demonstrate that dentate progenitors first dwell for up to 1 week in a previously unrecognized neurogenic zone intimately associated with the pial meningeal surface lining the outer edge of the forming dentate. This zone also serves as the organizational matrix for the initial formation of the dentate glial scaffolding. Timely clearance of neural precursors from their transient location depends on reeli...
Subjects
Medical Subject Headings: nervous system
free text keywords: Developmental Biology, Molecular Biology, Dentate gyrus, Signal transduction, Embryonic stem cell, Cellular differentiation, Neurogenesis, Reelin, biology.protein, biology, Subgranular zone, medicine.anatomical_structure, medicine, Anatomy, Neuroglia, Research Articles
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Other literature type . 2008
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Article . 2008
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publication . Article . Other literature type . 2008

Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling

Li, Guangnan; Kataoka, Hiroshi; Coughlin, Shaun R.; Pleasure, Samuel J.;