publication . Article . 2016

The threat of artemisinin resistant malaria in Southeast Asia

Nicholas J. White; Borimas Hanboonkunupakarn;
Open Access
  • Published: 01 Nov 2016 Journal: Travel Medicine and Infectious Disease, volume 14, pages 548-550 (issn: 1477-8939, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Fifty years ago it was becoming clear that the enormous global effort to eradicate malaria had failed. There were also an increasing number of worrying reports that the wonder drug chloroquine was not working as it should against falciparum malaria in parts of South-East Asia and South America. Chloroquine resistance spread slowly at first, but by 1979 it had reached the Eastern coastline of Africa, and by 1992 it had crossed the entire continent. Chloroquine could no longer be relied upon to treat malaria, and its preventive efficacy was also in decline. Chloroquine was replaced eventually by sulfadoxine-pyrimethamine as first-line treatment, but this fell rapi...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Public Health, Environmental and Occupational Health, Infectious Diseases, Editorial, Malaria, medicine.disease, medicine, Southeast asia, Traditional medicine, Biology, Artemisinin, medicine.drug, Artemisinin resistance
Related Organizations
18 references, page 1 of 2

Wootton, J.C., Feng, X., Ferdig, M.T., Cooper, R.A., Mu, J., Baruch, D.I.. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature. 2002; 418: 320-323 [OpenAIRE] [PubMed]

Roper, C., Pearce, R., Nair, S., Sharp, B., Nosten, F., Anderson, T.. Intercontinental spread of pyrimethamine-resistant malaria. Science. 2004; 305 (5687): 1124 [PubMed]

World Health Organization, null. 2015

Noedl, H., Se, Y., Schaecher, K., Smith, B.L., Socheat, D., Fukuda, M.M.. Artemisinin resistance in Cambodia 1 (ARC1) study consortium. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. 2008; 11 (359): 2619-2620

Dondorp, A.M., Nosten, F., Yi, P., Das, D., Phyo, A.P., Tarning, J.. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009; 361: 455-467 [OpenAIRE] [PubMed]

Tun, K.M., Imwong, M., Lwin, K.M., Win, A.A., Hlaing, T.M., Hlaing, T.. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis. 2015; 15: 415-421 [OpenAIRE] [PubMed]

Grist, E.P., Flegg, J.A., Humphreys, G., Mas, I.S., Anderson, T.J., Ashley, E.A.. Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia. Int J Health Geogr. 2016; 15: 37 [OpenAIRE] [PubMed]

Chenet, S.M., Akinyi Okoth, S., Huber, C.S., Chandrabose, J., Lucchi, N.W., Talundzic, E.. Independent emergence of the Plasmodium falciparum kelch propeller domain mutant allele C580Y in Guyana. J Infect Dis. 2016; 213: 1472-1475 [OpenAIRE] [PubMed]

Ménard, D., Khim, N., Beghain, J., Adegnika, A.A., Shafiul-Alam, M., Amodu, O.. A Worldwide map of Plasmodium falciparum K13-Propeller polymorphisms. N Engl J Med. 2016; 374: 2453-2464 [OpenAIRE] [PubMed]

Phyo, A.P., Ashley, E.A., Anderson, T.J., Bozdech, Z., Carrara, V.I., Sriprawat, K.. Declining efficacy of artemisinin combination therapy against P. Falciparum malaria on the Thai-Myanmar border (2003–2013): the role of parasite genetic factors. Clin Infect Dis. 2016; 63: 784-791 [OpenAIRE] [PubMed]

Witkowski, B., Duru, V., Khim, N., Ross, L.S., Saintpierre, B., Beghain, J.. A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study. Lancet Infect Dis. 2016 Nov 3

Amato, R., Lim, P., Miotto, O., Amaratunga, C., Dek, D., Pearson, R.D.. Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study. Lancet Infect Dis. 2016 Nov 3

Woodrow, C.J., White, N.J.. The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread. FEMS Microbiol Rev. 2016 Sep 8 [OpenAIRE]

Ashley, E.A., Dhorda, M., Fairhurst, R.M., Amaratunga, C., Lim, P., Suon, S.. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014; 371 (5): 411-423 [OpenAIRE] [PubMed]

MalariaGEN Plasmodium falciparum Community Project, null. Genomic epidemiology of artemisinin resistant malaria. Elife. 2016; 5: e08714 [OpenAIRE] [PubMed]

18 references, page 1 of 2
Abstract
Fifty years ago it was becoming clear that the enormous global effort to eradicate malaria had failed. There were also an increasing number of worrying reports that the wonder drug chloroquine was not working as it should against falciparum malaria in parts of South-East Asia and South America. Chloroquine resistance spread slowly at first, but by 1979 it had reached the Eastern coastline of Africa, and by 1992 it had crossed the entire continent. Chloroquine could no longer be relied upon to treat malaria, and its preventive efficacy was also in decline. Chloroquine was replaced eventually by sulfadoxine-pyrimethamine as first-line treatment, but this fell rapi...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Public Health, Environmental and Occupational Health, Infectious Diseases, Editorial, Malaria, medicine.disease, medicine, Southeast asia, Traditional medicine, Biology, Artemisinin, medicine.drug, Artemisinin resistance
Related Organizations
18 references, page 1 of 2

Wootton, J.C., Feng, X., Ferdig, M.T., Cooper, R.A., Mu, J., Baruch, D.I.. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum. Nature. 2002; 418: 320-323 [OpenAIRE] [PubMed]

Roper, C., Pearce, R., Nair, S., Sharp, B., Nosten, F., Anderson, T.. Intercontinental spread of pyrimethamine-resistant malaria. Science. 2004; 305 (5687): 1124 [PubMed]

World Health Organization, null. 2015

Noedl, H., Se, Y., Schaecher, K., Smith, B.L., Socheat, D., Fukuda, M.M.. Artemisinin resistance in Cambodia 1 (ARC1) study consortium. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. 2008; 11 (359): 2619-2620

Dondorp, A.M., Nosten, F., Yi, P., Das, D., Phyo, A.P., Tarning, J.. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009; 361: 455-467 [OpenAIRE] [PubMed]

Tun, K.M., Imwong, M., Lwin, K.M., Win, A.A., Hlaing, T.M., Hlaing, T.. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis. 2015; 15: 415-421 [OpenAIRE] [PubMed]

Grist, E.P., Flegg, J.A., Humphreys, G., Mas, I.S., Anderson, T.J., Ashley, E.A.. Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia. Int J Health Geogr. 2016; 15: 37 [OpenAIRE] [PubMed]

Chenet, S.M., Akinyi Okoth, S., Huber, C.S., Chandrabose, J., Lucchi, N.W., Talundzic, E.. Independent emergence of the Plasmodium falciparum kelch propeller domain mutant allele C580Y in Guyana. J Infect Dis. 2016; 213: 1472-1475 [OpenAIRE] [PubMed]

Ménard, D., Khim, N., Beghain, J., Adegnika, A.A., Shafiul-Alam, M., Amodu, O.. A Worldwide map of Plasmodium falciparum K13-Propeller polymorphisms. N Engl J Med. 2016; 374: 2453-2464 [OpenAIRE] [PubMed]

Phyo, A.P., Ashley, E.A., Anderson, T.J., Bozdech, Z., Carrara, V.I., Sriprawat, K.. Declining efficacy of artemisinin combination therapy against P. Falciparum malaria on the Thai-Myanmar border (2003–2013): the role of parasite genetic factors. Clin Infect Dis. 2016; 63: 784-791 [OpenAIRE] [PubMed]

Witkowski, B., Duru, V., Khim, N., Ross, L.S., Saintpierre, B., Beghain, J.. A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study. Lancet Infect Dis. 2016 Nov 3

Amato, R., Lim, P., Miotto, O., Amaratunga, C., Dek, D., Pearson, R.D.. Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study. Lancet Infect Dis. 2016 Nov 3

Woodrow, C.J., White, N.J.. The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread. FEMS Microbiol Rev. 2016 Sep 8 [OpenAIRE]

Ashley, E.A., Dhorda, M., Fairhurst, R.M., Amaratunga, C., Lim, P., Suon, S.. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014; 371 (5): 411-423 [OpenAIRE] [PubMed]

MalariaGEN Plasmodium falciparum Community Project, null. Genomic epidemiology of artemisinin resistant malaria. Elife. 2016; 5: e08714 [OpenAIRE] [PubMed]

18 references, page 1 of 2
Any information missing or wrong?Report an Issue