publication . Article . Other literature type . 2002

Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity☆☆☆★★★

Chamlin, Sarah L.; Kao, Jack; Frieden, Ilona J.; Sheu, Mary Y.; Fowler, Ashley J.; Fluhr, Joachim W.; Williams, Mary L.; Elias, Peter M.;
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  • Published: 01 Aug 2002 Journal: Journal of the American Academy of Dermatology, volume 47, pages 198-208 (issn: 0190-9622, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Abstract Background: It is currently fashionable to consider atopic dermatitis (AD), like other inflammatory dermatoses, as immunologic in pathogenesis ("inside-outside" hypothesis). Accordingly, topical glucocorticoids and other immunosuppressive agents are mainstays of therapy, but the risk of toxicity from these agents is not insignificant, particularly in children. Alternatively, because stratum corneum (SC) permeability barrier function is also abnormal in AD, it has been hypothesized that the barrier abnormality could drive disease activity. Yet commonly used emollients and moisturizers do not correct the SC ceramide deficiency, the putative cause of the b...
Subjects
free text keywords: Dermatology, Toxicity, medicine.medical_specialty, medicine, Barrier function, SCORAD, medicine.diagnostic_test, Allergy, medicine.disease, Atopy, Atopic dermatitis, business.industry, business, Moisturizer, medicine.medical_treatment, Transepidermal water loss
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