publication . Other literature type . Article . 2002

Genetic Structure of Human Populations

Lev A. Zhivotovsky; Noah A. Rosenberg; Howard M. Cann; James L. Weber; Marcus W. Feldman; Kenneth K. Kidd; Jonathan K. Pritchard;
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  • Published: 20 Dec 2002
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
The difficulty of extrapolating from inbred mouse strains used for the assessment of toxicological responses to the human population that may be exposed to the potentially toxic substance is discussed. Conventional risk estimation procedures assume little heterogeneity among members of the population in their response to a substance. This ignores the inherent genetic diversity present in human populations. Measurement of enzymic variation reveals that humans are more variable genetically than most mammalian species. Common genetic variants abound. Genetic variability within or between inbred strains of mice is much less. Evaluation of toxicological hazards shoul...
Subjects
free text keywords: Multidisciplinary, Toxicology, Pollution, Genetic variation, Genetic variability, Population, education.field_of_study, education, Genetic structure, Race (biology), Genetic association, Genetics, Human genetic variation, Genetic drift, Biology, Genetic diversity, Inbred strain, Genotype, Inbreeding
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