publication . Article . Other literature type . 2012

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

Lloyd J. Old; Hirokazu Matsushita; Hirokazu Matsushita; Michael C. Wendl; Ravindra Uppaluri; Elaine R. Mardis; Daniel C. Koboldt; Yee Shiuan Chen; Mark J. Smyth; Mark J. Smyth; ...
Open Access
  • Published: 08 Feb 2012 Journal: Nature, volume 482, pages 400-404 (issn: 0028-0836, eissn: 1476-4687, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Cancer immunoediting, the process whereby the immune system controls tumour outgrowth and shapes tumour immunogenicity, is comprised of three phases: elimination, equilibrium and escape1–5. Although many immune components that participate in this process are known, its underlying mechanisms remain poorly defined. A central tenet of cancer immunoediting is that T cell recognition of tumour antigens drives the immunologic destruction or sculpting of a developing cancer. However, our current understanding of tumour antigens comes largely from analyses of cancers that develop in immunocompetent hosts and thus may have already been edited. Little is known about the a...
Subjects
free text keywords: Article, Immunoediting, Cancer research, Immunology, Cancer, medicine.disease, medicine, Immune system, Biology, Immunogenicity, T cell, medicine.anatomical_structure, Cell, Antigen, Expression cloning
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