publication . Article . 2016

Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology

Martin E; Boucher C; Fontaine B; Cécile DELARASSE;
Open Access English
  • Published: 01 Aug 2016
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; Alzheimer's disease (AD) is a neurodegenerative disease characterized by formation of amyloid-b (Ab) plaques, activated microglia, and neuronal cell death leading to progressive demen-tia. Recent data indicate that microglia and monocyte-derived macrophages (MDM) are key players in the initiation and progression of AD, yet their respective roles remain to be clarified. As AD occurs mostly in the elderly and aging impairs myeloid functions, we addressed the inflammatory profile of microglia and MDM during aging in TgAPP/PS1 and TgAPP/ PS1dE9, two transgenic AD mouse models, compared to WT littermates. We only found MDM infiltration in very...
Subjects
free text keywords: cytokines, chemokines, aging, Alzheimer's disease, macrophages, microglia, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Original Article, Original Articles, Cell Biology, Ageing
40 references, page 1 of 3

Aguzzi A, Barres BA, Bennett ML (2013) Microglia: scapegoat, saboteur, or something else? Science 339, 156-161. [OpenAIRE]

Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM (2011) Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat. Neurosci. 14, 1142-1149. [OpenAIRE]

Babcock AA, Ilkjaer L, Clausen BH, Villadsen B, Dissing-Olesen L, Bendixen AT, Lyck L, Lambertsen KL, Finsen B (2015) Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice. Brain Behav. Immun. 48, 86-101. [OpenAIRE]

Baron R, Babcock AA, Nemirovsky A, Finsen B, Monsonego A (2014) Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease. Aging Cell 13, 584-595. [OpenAIRE]

Conde JR, Streit WJ (2006) Microglia in the aging brain. J. Neuropathol. Exp. Neurol. 65, 199-203.

Damani MR, Zhao L, Fontainhas AM, Amaral J, Fariss RN, Wong WT (2011) Agerelated alterations in the dynamic behavior of microglia. Aging Cell 10, 263- 276.

Delarasse C, Daubas P, Mars LT, Vizler C, Litzenburger T, Iglesias A, Bauer J, Della Gaspera B, Schubart A, Decker L, Dimitri D, Roussel G, Dierich A, Amor S, Dautigny A, Liblau R, Pham-Dinh D (2003) Myelin/oligodendrocyte glycoproteindeficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wildtype mice. J Clin Invest. 112, 544-553. [OpenAIRE]

Dinarello CA, Margolis NH (1995) Cytokine-processing enzymes. Stopping the cuts. Current biology: CB. 5, 587-590. [OpenAIRE]

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD (2003) CD36 mediates the innate host response to beta-amyloid. J. Exp. Med. 197, 1657-1666. [OpenAIRE]

El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13, 432-438.

Fassbender K, Walter S, Kuhl S, Landmann R, Ishii K, Bertsch T, Stalder AK, Muehlhauser F, Liu Y, Ulmer AJ, Rivest S, Lentschat A, Gulbins E, Jucker M, Staufenbiel M, Brechtel K, Walter J, Multhaup G, Penke B, Adachi Y, Hartmann T, Beyreuther K (2004) The LPS receptor (CD14) links innate immunity with Alzheimer's disease. Faseb J. 18, 203-205.

Fazilleau N, Delarasse C, Motta I, Fillatreau S, Gougeon ML, Kourilsky P, Pham-Dinh D, Kanellopoulos JM (2007) T cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol. 178, 4865-4875. [OpenAIRE]

Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J. Neurosci. 32, 16129-16140. [OpenAIRE]

Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009) Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat. Neurosci. 12, 1361-1363. [OpenAIRE]

Greter M, Lelios I, Croxford AL (2015) Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation. Front Immunol. 6, 249.

40 references, page 1 of 3
Abstract
International audience; Alzheimer's disease (AD) is a neurodegenerative disease characterized by formation of amyloid-b (Ab) plaques, activated microglia, and neuronal cell death leading to progressive demen-tia. Recent data indicate that microglia and monocyte-derived macrophages (MDM) are key players in the initiation and progression of AD, yet their respective roles remain to be clarified. As AD occurs mostly in the elderly and aging impairs myeloid functions, we addressed the inflammatory profile of microglia and MDM during aging in TgAPP/PS1 and TgAPP/ PS1dE9, two transgenic AD mouse models, compared to WT littermates. We only found MDM infiltration in very...
Subjects
free text keywords: cytokines, chemokines, aging, Alzheimer's disease, macrophages, microglia, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Original Article, Original Articles, Cell Biology, Ageing
40 references, page 1 of 3

Aguzzi A, Barres BA, Bennett ML (2013) Microglia: scapegoat, saboteur, or something else? Science 339, 156-161. [OpenAIRE]

Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM (2011) Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat. Neurosci. 14, 1142-1149. [OpenAIRE]

Babcock AA, Ilkjaer L, Clausen BH, Villadsen B, Dissing-Olesen L, Bendixen AT, Lyck L, Lambertsen KL, Finsen B (2015) Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice. Brain Behav. Immun. 48, 86-101. [OpenAIRE]

Baron R, Babcock AA, Nemirovsky A, Finsen B, Monsonego A (2014) Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease. Aging Cell 13, 584-595. [OpenAIRE]

Conde JR, Streit WJ (2006) Microglia in the aging brain. J. Neuropathol. Exp. Neurol. 65, 199-203.

Damani MR, Zhao L, Fontainhas AM, Amaral J, Fariss RN, Wong WT (2011) Agerelated alterations in the dynamic behavior of microglia. Aging Cell 10, 263- 276.

Delarasse C, Daubas P, Mars LT, Vizler C, Litzenburger T, Iglesias A, Bauer J, Della Gaspera B, Schubart A, Decker L, Dimitri D, Roussel G, Dierich A, Amor S, Dautigny A, Liblau R, Pham-Dinh D (2003) Myelin/oligodendrocyte glycoproteindeficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wildtype mice. J Clin Invest. 112, 544-553. [OpenAIRE]

Dinarello CA, Margolis NH (1995) Cytokine-processing enzymes. Stopping the cuts. Current biology: CB. 5, 587-590. [OpenAIRE]

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD (2003) CD36 mediates the innate host response to beta-amyloid. J. Exp. Med. 197, 1657-1666. [OpenAIRE]

El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13, 432-438.

Fassbender K, Walter S, Kuhl S, Landmann R, Ishii K, Bertsch T, Stalder AK, Muehlhauser F, Liu Y, Ulmer AJ, Rivest S, Lentschat A, Gulbins E, Jucker M, Staufenbiel M, Brechtel K, Walter J, Multhaup G, Penke B, Adachi Y, Hartmann T, Beyreuther K (2004) The LPS receptor (CD14) links innate immunity with Alzheimer's disease. Faseb J. 18, 203-205.

Fazilleau N, Delarasse C, Motta I, Fillatreau S, Gougeon ML, Kourilsky P, Pham-Dinh D, Kanellopoulos JM (2007) T cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol. 178, 4865-4875. [OpenAIRE]

Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J. Neurosci. 32, 16129-16140. [OpenAIRE]

Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009) Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat. Neurosci. 12, 1361-1363. [OpenAIRE]

Greter M, Lelios I, Croxford AL (2015) Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation. Front Immunol. 6, 249.

40 references, page 1 of 3
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