publication . Other literature type . Article . 2017

Microglia-mediated neuroprotection, TREM2 and Alzheimer’s disease: Evidence from Optical Imaging

Carlo Condello; Peng Yuan; Jaime Grutzendler;
  • Published: 14 Oct 2017
  • Publisher: Elsevier BV
Recent genetic studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathophysiology of Alzheimer disease (AD). However, the precise mechanisms by which microglia alter the course of AD neuropathology remain poorly understood. Here we discuss current evidence of the neuroprotective functions of microglia with a focus on optical imaging studies that have revealed a role of these cells in the encapsulation of amyloid deposits (“microglia barrier”). This barrier modulates the degree of plaque compaction, amyloid fibril surface area and insulation from adjacent axons thereby reducing neurotoxicity. We discuss f...
Medical Subject Headings: nervous system
free text keywords: Alzheimer's disease, medicine.disease, medicine, Neuropathology, Amyloid, Neuroprotection, Neuroscience, Receptor, TREM2, Microglia, medicine.anatomical_structure, Neurotoxicity, Biology, Article
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