publication . Article . Other literature type . 1999

Disequilibrium Mapping of a Quantitative-Trait Locus in an Expanding Population

Montgomery Slatkin;
Open Access
  • Published: 01 Jun 1999 Journal: The American Journal of Human Genetics, volume 64, issue 6, pages 1,765-1,773 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Summary Linkage disequilibrium (LD) mapping can be successful if there is strong nonrandom association between marker alleles and an allele affecting a trait of interest. The principles of LD mapping of dichotomous traits are well understood, but less is known about LD mapping of a quantitative-trait locus (QTL). It is shown in this report that selective genotyping can increase the power to detect and map a rare allele of large effect at a QTL. Two statistical tests of the association between an allele and a quantitative character are proposed. These tests are approximately independent, so information from them can be combined. Analytic theory is developed to sh...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Genetics(clinical), Genetics, Linkage disequilibrium, Population genetics, Quantitative-trait locus, QTL (see Quantitative-trait locus), Research Article, Family-based QTL mapping, Association mapping, Biology, Allele, Quantitative trait locus, Locus (genetics), Allele frequency, Additive genetic effects, Ancestry-informative marker
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