publication . Other literature type . Article . 2011

A continuum model for tumour suppression

Pier Paolo Pandolfi; Alfred G. Knudson; Alice H. Berger;
Open Access
  • Published: 10 Aug 2011
  • Publisher: Springer Nature
Abstract
This year, 2011, marks the forty-year anniversary of the statistical analysis of retinoblastoma that provided the first evidence that tumorigenesis can be initiated by as few as two mutations. This work provided the foundation for the two-hit hypothesis that explained the role of recessive tumour suppressor genes (TSGs) in dominantly inherited cancer susceptibility syndromes. However, four decades later, it is now known that even partial inactivation of tumour suppressors can critically contribute to tumorigenesis. Here we analyse this evidence and propose a continuum model of TSG function to explain the full range of TSG mutations found in cancer.
Subjects
free text keywords: Article, Multidisciplinary, Carcinogenesis, medicine.disease_cause, medicine, Cancer, medicine.disease, Dominance (genetics), Statistical analysis, Retinoblastoma, Suppressor, law.invention, law, Haploinsufficiency, Gene, Genetics, Biology
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Europe PubMed Central
Other literature type . 2011
Nature
Article
Provider: UnpayWall
Nature
Article . 2011
Provider: Crossref
Abstract
This year, 2011, marks the forty-year anniversary of the statistical analysis of retinoblastoma that provided the first evidence that tumorigenesis can be initiated by as few as two mutations. This work provided the foundation for the two-hit hypothesis that explained the role of recessive tumour suppressor genes (TSGs) in dominantly inherited cancer susceptibility syndromes. However, four decades later, it is now known that even partial inactivation of tumour suppressors can critically contribute to tumorigenesis. Here we analyse this evidence and propose a continuum model of TSG function to explain the full range of TSG mutations found in cancer.
Subjects
free text keywords: Article, Multidisciplinary, Carcinogenesis, medicine.disease_cause, medicine, Cancer, medicine.disease, Dominance (genetics), Statistical analysis, Retinoblastoma, Suppressor, law.invention, law, Haploinsufficiency, Gene, Genetics, Biology
Download fromView all 4 versions
Europe PubMed Central
Other literature type . 2011
Nature
Article
Provider: UnpayWall
Nature
Article . 2011
Provider: Crossref
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