publication . Article . Other literature type . 2018

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

Jack, Clifford R.; Lowe, Val J.; Weigand, Stephen D.; Wiste, Heather J.; Senjem, Matthew L.; Knopman, David S.; Shiung, Maria M.; Gunter, Jeffrey L.; Boeve, Bradley F.; Kemp, Bradley J.; ...
Open Access English
  • Published: 13 Nov 2018 Journal: Brain, volume 132, issue 5, pages 1,355-1,365 (issn: 0006-8950, eissn: 1460-2156, Copyright policy)
  • Publisher: Oxford University Press
Abstract
The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial 11C Pittsburgh compound B (PIB) positron emission tomography and progression of neurodegeneration using serial structural magnetic resonance imaging. We studied 21 healthy cognitively normal subjects, 32 with amnestic mild cognitive impairment and 8 with Alzheimer's disease. Subjects were drawn from two sources—ongoing longitudinal registries at Mayo Clinic, and the Alzheimer's disease Neuroimaging Initiative (ADNI...
Subjects
free text keywords: Original Articles, Alzheimer's disease, amyloid imaging, magnetic resonance imaging, longitudinal imaging, mild cognitive impairment, Pittsburgh compound B, Atrophy, medicine.disease, medicine, Neuroscience, Mini–Mental State Examination, medicine.diagnostic_test, Cognitive decline, Amyloidosis, business.industry, business, Neurodegeneration, chemistry.chemical_compound, chemistry, Cognitive disorder
Funded by
NIH| Mayo Alzheimers Disease Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P50AG016574-06S1
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| ALZHEIMERS DISEASE PATIENT REGISTRY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2U01AG006786-04
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| MR HIPPOCAMPAL CHANGES IN ALZHEIMERS DISEASE AND AGING
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AG011378-03
  • Funding stream: NATIONAL INSTITUTE ON AGING
79 references, page 1 of 6

Aizenstein, HJ, Nebes, RD, Saxton, JA, Price, JC, Mathis, CA, Tsopelas, ND. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008; 65: 1509-17 [OpenAIRE] [PubMed]

Diagnostic and statistical manual of mental disorders. DSM-IV. 1994

Andreasen, N, Hesse, C, Davidsson, P, Minthon, L, Wallin, A, Winblad, B. Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset alzheimer disease and stability during the course of disease. Arch Neurol. 1999; 56: 673-80 [PubMed]

Archer, HA, Edison, P, Brooks, DJ, Barnes, J, Frost, C, Yeatman, T. Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol. 2006; 60: 145-7 [OpenAIRE] [PubMed]

Bacskai, BJ, Frosch, MP, Freeman, SH, Raymond, SB, Augustinack, JC, Johnson, KA. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007; 64: 431-4 [OpenAIRE] [PubMed]

Bennett, DA, Schneider, JA, Bienias, JL, Evans, DA, Wilson, RS. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology. 2005; 64: 834-41 [OpenAIRE] [PubMed]

Bobinski, M, de Leon, MJ, Wegiel, J, Desanti, S, Convit, A, Saint Louis, LA. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience. 2000; 95: 721-5 [PubMed]

Braak, H, Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991; 82: 239-59 [PubMed]

Carlson, NE, Moore, MM, Dame, A, Howieson, D, Silbert, LC, Quinn, JF. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology. 2008; 70: 828-33 [PubMed]

Chan, D, Janssen, JC, Whitwell, JL, Watt, HC, Jenkins, R, Frost, C. Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study. Lancet. 2003; 362: 1121-2 [OpenAIRE] [PubMed]

Clark, CM, Xie, S, Chittams, J, Ewbank, D, Peskind, E, Galasko, D. Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?. Arch Neurol. 2003; 60: 1696-702 [PubMed]

Csernansky, JG, Hamstra, J, Wang, L, McKeel, D, Price, JL, Gado, M. Correlations between antemortem hippocampal volume and postmortem neuropathology in AD subjects. Alzheimer Dis Assoc Disord|. 2004; 18: 190-5

Leon, MJ, DeSanti, S, Zinkowski, R, Mehta, PD, Pratico, D, Segal, S. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging. 2006; 27: 394-401 [OpenAIRE] [PubMed]

Drzezga, A, Grimmer, T, Henriksen, G, Stangier, I, Perneczky, R, Diehl-Schmid, J. Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease. Neuroimage. 2008; 39: 619-33 [OpenAIRE] [PubMed]

Edison, P, Archer, HA, Hinz, R, Hammers, A, Pavese, N, Tai, YF. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology. 2007; 68: 501-8 [PubMed]

79 references, page 1 of 6
Abstract
The purpose of this study was to use serial imaging to gain insight into the sequence of pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. We measured change in amyloid deposition over time using serial 11C Pittsburgh compound B (PIB) positron emission tomography and progression of neurodegeneration using serial structural magnetic resonance imaging. We studied 21 healthy cognitively normal subjects, 32 with amnestic mild cognitive impairment and 8 with Alzheimer's disease. Subjects were drawn from two sources—ongoing longitudinal registries at Mayo Clinic, and the Alzheimer's disease Neuroimaging Initiative (ADNI...
Subjects
free text keywords: Original Articles, Alzheimer's disease, amyloid imaging, magnetic resonance imaging, longitudinal imaging, mild cognitive impairment, Pittsburgh compound B, Atrophy, medicine.disease, medicine, Neuroscience, Mini–Mental State Examination, medicine.diagnostic_test, Cognitive decline, Amyloidosis, business.industry, business, Neurodegeneration, chemistry.chemical_compound, chemistry, Cognitive disorder
Funded by
NIH| Mayo Alzheimers Disease Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3P50AG016574-06S1
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| ALZHEIMERS DISEASE PATIENT REGISTRY
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2U01AG006786-04
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| MR HIPPOCAMPAL CHANGES IN ALZHEIMERS DISEASE AND AGING
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AG011378-03
  • Funding stream: NATIONAL INSTITUTE ON AGING
79 references, page 1 of 6

Aizenstein, HJ, Nebes, RD, Saxton, JA, Price, JC, Mathis, CA, Tsopelas, ND. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008; 65: 1509-17 [OpenAIRE] [PubMed]

Diagnostic and statistical manual of mental disorders. DSM-IV. 1994

Andreasen, N, Hesse, C, Davidsson, P, Minthon, L, Wallin, A, Winblad, B. Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset alzheimer disease and stability during the course of disease. Arch Neurol. 1999; 56: 673-80 [PubMed]

Archer, HA, Edison, P, Brooks, DJ, Barnes, J, Frost, C, Yeatman, T. Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol. 2006; 60: 145-7 [OpenAIRE] [PubMed]

Bacskai, BJ, Frosch, MP, Freeman, SH, Raymond, SB, Augustinack, JC, Johnson, KA. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007; 64: 431-4 [OpenAIRE] [PubMed]

Bennett, DA, Schneider, JA, Bienias, JL, Evans, DA, Wilson, RS. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology. 2005; 64: 834-41 [OpenAIRE] [PubMed]

Bobinski, M, de Leon, MJ, Wegiel, J, Desanti, S, Convit, A, Saint Louis, LA. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience. 2000; 95: 721-5 [PubMed]

Braak, H, Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991; 82: 239-59 [PubMed]

Carlson, NE, Moore, MM, Dame, A, Howieson, D, Silbert, LC, Quinn, JF. Trajectories of brain loss in aging and the development of cognitive impairment. Neurology. 2008; 70: 828-33 [PubMed]

Chan, D, Janssen, JC, Whitwell, JL, Watt, HC, Jenkins, R, Frost, C. Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study. Lancet. 2003; 362: 1121-2 [OpenAIRE] [PubMed]

Clark, CM, Xie, S, Chittams, J, Ewbank, D, Peskind, E, Galasko, D. Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?. Arch Neurol. 2003; 60: 1696-702 [PubMed]

Csernansky, JG, Hamstra, J, Wang, L, McKeel, D, Price, JL, Gado, M. Correlations between antemortem hippocampal volume and postmortem neuropathology in AD subjects. Alzheimer Dis Assoc Disord|. 2004; 18: 190-5

Leon, MJ, DeSanti, S, Zinkowski, R, Mehta, PD, Pratico, D, Segal, S. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging. 2006; 27: 394-401 [OpenAIRE] [PubMed]

Drzezga, A, Grimmer, T, Henriksen, G, Stangier, I, Perneczky, R, Diehl-Schmid, J. Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease. Neuroimage. 2008; 39: 619-33 [OpenAIRE] [PubMed]

Edison, P, Archer, HA, Hinz, R, Hammers, A, Pavese, N, Tai, YF. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology. 2007; 68: 501-8 [PubMed]

79 references, page 1 of 6
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