publication . Other literature type . Article . 2009

LONG-TERM MANAGEMENT OF THE CARCINOID SYNDROME Treatment with octreotide alone and in combination with alpha-interferon

Eva Tiensuu Janson; Kjell Öberg;
  • Published: 08 Jul 2009
  • Publisher: Informa UK Limited
Abstract
Fifty-five patients with metastatic carcinoid tumor were treated with the long-acting somatostatin analogue octreotide. Nineteen received in addition alpha-interferon when octreotide had failed. During octreotide treatment reduced flush and/or diarrhea was seen in 70% of the patients, 37% showed > 50% decrease in urinary 5-HIAA for a median of 8 months. A further 49% experienced stabilization of their disease and only 14% progressed. One patient showed reduced tumor size. Of the 19 patients given alpha-interferon in combination with octreotide, 72% showed significant reduction in urinary 5-HIAA for a median of 10 months. Twenty-two percent became stabilized and ...
Subjects
free text keywords: Oncology, Radiology Nuclear Medicine and imaging, Hematology, General Medicine, Diarrhea, medicine.symptom, medicine, Octreotide, medicine.drug, Long term management, Carcinoid syndrome, medicine.disease, Diabetes mellitus, Surgery, medicine.medical_specialty, Pathology, Urinary system, Internal medicine, Metastatic carcinoid tumor, Gastroenterology, business.industry, business, Alpha interferon
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publication . Other literature type . Article . 2009

LONG-TERM MANAGEMENT OF THE CARCINOID SYNDROME Treatment with octreotide alone and in combination with alpha-interferon

Eva Tiensuu Janson; Kjell Öberg;