publication . Article . 2016

Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition

Sun Ah Kim; Yun Joo Yoo;
Open Access English
  • Published: 01 Dec 2016 Journal: Genomics & Informatics, volume 14, issue 4, pages 196-204 (issn: 1598-866X, eissn: 2234-0742, Copyright policy)
  • Publisher: Korea Genome Organization
Abstract
Many researchers have found that one of the most important characteristics of the structure of linkage disequilibrium is that the human genome can be divided into non-overlapping block partitions in which only a small number of haplotypes are observed. The location and distribution of haplotype blocks can be seen as a population property influenced by population genetic events such as selection, mutation, recombination and population structure. In this study, we investigate the effects of the density of markers relative to the full set of all polymorphisms in the region on the results of haplotype partitioning for five popular haplotype block partition methods: ...
Subjects
free text keywords: Original Article, Special Issue: Recent Statistical Challenges in High Dimensional Omics Data, 1,000 Genomes Project, haplotypes, haplotype block, linkage disequilibrium, Genetics, QH426-470, Partition (number theory), Haplotype estimation, Single-nucleotide polymorphism, Haplotype, Tag SNP, Modal haplotype, Biology
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publication . Article . 2016

Effects of Single Nucleotide Polymorphism Marker Density on Haplotype Block Partition

Sun Ah Kim; Yun Joo Yoo;