publication . Other literature type . Article . 2010

Binding of oxytetracycline to bovine serum albumin: spectroscopic and molecular modeling investigations.

Zhenxing Chi; Rutao Liu; Yue Teng; Xiaoyan Fang; Canzhu Gao;
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  • Published: 22 Sep 2010
  • Publisher: American Chemical Society (ACS)
Abstract
The residue of the widely used veterinary drug oxytetracycline (OTC) in the environment (e.g., animal food, soils, surface water, and groundwater) is potentially harmful. Knowledge of its binding to proteins contributes to the understanding of its toxicity in vivo. This work establishes the binding mode of OTC with bovine serum albumin (BSA) under physiological conditions by spectroscopic methods and molecular modeling techniques. The inner filter effect was eliminated to get accurate data (binding parameters). On the basis of the thermodynamic results and site marker competition experiments, it was considered that OTC binds to site II (subdomain IIIA) of BSA ma...
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