publication . Part of book or chapter of book . Other literature type . 2013

Sphingolipid metabolism and neutral sphingomyelinases.

Name: Sphingolipid metabolism and neutral sphingomyelinases.
Keywords: Article

Yusuf A. Hannun; Michael V. Airola;

Open Access

Published: 01 Jan 2013

Publisher: Springer Vienna

Summary

Abstract

Sphingolipids are an important class of lipid molecules that play fundamental roles in our cells and body. Beyond a structural role, it is now clearly established that sphingolipids serve as bioactive signaling molecules to regulate diverse processes including inflammatory signaling, cell death, proliferation, and pain sensing. Sphingolipid metabolites have been implicated in the onset and progression of various diseases including cancer, lung disease, diabetes, and lysosomal storage disorders. Here we will review sphingolipid metabolism to introduce basic concepts as well as emerging complexities in sphingolipid function gained from modern technological advance...

doi: 10.1007/978-3-7091-1368-4_3

pmc: PMC4043343

pmid: 23579449

Subjects

Medical Subject Headings: lipids (amino acids, peptides, and proteins)

free text keywords: Article, Programmed cell death, Ceramide, chemistry.chemical_compound, chemistry, Sphingosine-1-phosphate, Cell biology, Biology, Sphingolipid, Exosome, Cell, medicine.anatomical_structure, medicine, Cell signaling, Sphingomyelin, Biochemistry

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