publication . Article . 2012

Down's syndrome and Alzheimer's disease: towards secondary prevention.

Seth Ness; Michael Rafii; Paul Aisen; Michael Krams; Wayne Silverman; Husseini Manji;
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  • Published: 31 Aug 2012 Journal: Nature Reviews Drug Discovery, volume 11, pages 655-656 (issn: 1474-1776, eissn: 1474-1784, Copyright policy)
  • Publisher: Springer Nature
Abstract
A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.
Subjects
Medical Subject Headings: mental disorders
free text keywords: Pharmacology, Drug Discovery, General Medicine, Psychiatry, medicine.medical_specialty, medicine, Immunology, Amyloid precursor protein, biology.protein, biology, Diabetes mellitus, medicine.disease, business.industry, business, Biomarker (medicine), S syndrome, Dementia, Internal medicine, Disease
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publication . Article . 2012

Down's syndrome and Alzheimer's disease: towards secondary prevention.

Seth Ness; Michael Rafii; Paul Aisen; Michael Krams; Wayne Silverman; Husseini Manji;