publication . Other literature type . Article . 2003

Protein complexes and functional modules in molecular networks

Leonid A. Mirny; Victor Spirin;
Open Access English
  • Published: 29 Sep 2003
  • Publisher: National Academy of Sciences
Abstract
Proteins, nucleic acids, and small molecules form a dense network of molecular interactions in a cell. Molecules are nodes of this network, and the interactions between them are edges. The architecture of molecular networks can reveal important principles of cellular organization and function, similarly to the way that protein structure tells us about the function and organization of a protein. Computational analysis of molecular networks has been primarily concerned with node degree [Wagner, A. & Fell, D. A. (2001) Proc. R. Soc. London Ser. B 268, 1803–1810; Jeong, H., Tombor, B., Albert, R., Oltvai, Z. N. & Barabasi, A. L. (2000) Nature 407, 651–654] or degree...
Subjects
free text keywords: Biological Sciences, Multidisciplinary, Molecular network, Protein structure, RNA splicing, Proteomics, Topology, Random graph, Biology, Modularity, Genetics, A protein, Small molecule
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