publication . Article . Other literature type . 1994

High resolution of human evolutionary trees with polymorphic microsatellites

J. Tomfohrde; J.R. Kidd; Anne M. Bowcock; Eric Minch; Luigi Luca Cavalli-Sforza; Andrés Ruiz-Linares;
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  • Published: 01 Mar 1994 Journal: Nature, volume 368, pages 455-457 (issn: 0028-0836, eissn: 1476-4687, Copyright policy)
  • Publisher: Springer Nature
Abstract
Genetic variation at hypervariable loci is being used extensively for linkage analysis and individual identification, and may be useful for inter-population studies. Here we show that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy. This is achieved by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations. Reliable evolutionary relationships could also be established in comparisons among human populations but not among great ape species, probably because of co...
Subjects
free text keywords: Genetics, Genetic variation, Genetic variability, Population genetics, Allele frequency, Biology, Phylogenetic tree, Locus (genetics), Microsatellite, Allele
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