publication . Preprint . Other literature type . Article . 2002

Hierarchical Organization of Modularity in Metabolic Networks

Albert-László Barabási; Zoltán N. Oltvai; Erzsébet Ravasz; D. A. Mongru; A. L. Somera;
Open Access English
  • Published: 30 Aug 2002
Abstract
Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law. Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The i...
Subjects
free text keywords: Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics, Quantitative Biology, Multidisciplinary, Modularity, Network architecture, Distributed computing, Hierarchical organization, Cellular organization, Discrete functions, Gene co-expression network, Biology, Modularity (networks), Cluster analysis
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