publication . Other literature type . Article . 2018

The use of driving endonuclease genes to suppress mosquito vectors of malaria in temporally variable environments

Ben Lambert; Ace North; Austin Burt; H. Charles J. Godfray;
  • Published: 01 Apr 2018
  • Publisher: Springer Science and Business Media LLC
  • Country: United Kingdom
Abstract
Background The use of gene drive systems to manipulate populations of malaria vectors is currently being investigated as a method of malaria control. One potential system uses driving endonuclease genes (DEGs) to spread genes that impose a genetic load. Previously, models have shown that the introduction of DEG-bearing mosquitoes could suppress or even extinguish vector populations in spatially-heterogeneous environments which were constant over time. In this study, a stochastic spatially-explicit model of mosquito ecology is combined with a rainfall model which enables the generation of a variety of daily precipitation patterns. The model is then used to invest...
Subjects
Medical Subject Headings: parasitic diseasesgenetic structures
free text keywords: Anopheles, Rainfall, Homing endonucleases, Epidemiology, Vector control, Climate-modelling, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Parasitology, Tropical Medicine, Spatial modelling, Weather, ANOPHELES-GAMBIAE, WESTERN KENYA, AQUATIC STAGES, POPULATION, SYSTEM, ELIMINATION, HABITATS, VILLAGE, MODEL, REQUIREMENTS, 1108 Medical Microbiology, Research, Wet season, Atmospheric sciences, Extinction, Gene drive, Dry season, education.field_of_study, education, Virology, Genetic load, Population density, biology.organism_classification, biology
50 references, page 1 of 4

World malaria report 2014. 2014

Global technical strategy for malaria 2016–2030. 2015

Le Menach, A, Takala, S, McKenzie, FE, Perisse, A, Harris, A, Flahault, A. An elaborated feeding cycle model for reductions in vectorial capacity of night-biting mosquitoes by insecticide-treated nets. Malar J. 2007; 6: 10 [OpenAIRE] [PubMed] [DOI]

Ferguson, HM, Dornhaus, A, Beeche, A, Borgemeister, C, Gottlieb, M, Mulla, MS. Ecology: a prerequisite for malaria elimination and eradication. PLoS Med. 2010; 7 (8): e1000303 [OpenAIRE] [PubMed] [DOI]

Read, AF, Lynch, PA, Thomas, MB. How to make evolution-proof insecticides for malaria control. PLoS Biol. 2009; 7 (4): e1000058 [OpenAIRE] [PubMed] [DOI]

Tanner, M, Greenwood, B, Whitty, CJM, Ansah, EK, Price, RN, Dondorp, AM. Malaria eradication and elimination: views on how to translate a vision into reality. BMC Med. 2015; 13: 167 [OpenAIRE] [PubMed] [DOI]

Burt, A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Biol Sci. 2003; 270: 921-928 [OpenAIRE] [PubMed] [DOI]

Mueller, JE, Bryk, M, Loizos, N, Belfort, M. 4 Homing endonucleases. Cold Spring Harbor Monograph Archive. 1993; 25: 111-143

Hammond, A, Galizi, R, Kyrou, K, Simoni, A, Siniscalchi, C, Katsanos, D. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nat Biotechnol. 2016; 34: 78-83 [OpenAIRE] [PubMed] [DOI]

North, A, Burt, A, Godfray, HCJ. How driving endonuclease genes can be used to combat pests and disease vectors. BMC Biol. 2017; 15: 81 [OpenAIRE] [PubMed] [DOI]

Windbichler, N, Menichelli, M, Papathanos, PA, Thyme, SB, Hui, L, Ulge, UY. A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature. 2011; 473: 212-215 [OpenAIRE] [PubMed] [DOI]

Galizi, R, Doyle, LA, Menichelli, M, Bernardini, F, Deredec, A, Burt, A. A synthetic sex ratio distortion system for the control of the human malaria mosquito. Nat Comm. 2014; 5: 3977 [OpenAIRE] [DOI]

Bernardini, F, Galizi, R, Menichelli, M, Papathanos, PA, Dritsou, V, Marois, E. Site-specific genetic engineering of the Anopheles gambiae Y chromosome. Proc Natl Acad Sci USA. 2014; 111: 7600-7605 [OpenAIRE] [PubMed] [DOI]

Deredec, A, Burt, A, Godfray, HCJ. The population genetics of using homing endonuclease genes in vector and pest management. Genetics. 2008; 179: 2013-2026 [OpenAIRE] [PubMed] [DOI]

Deredec, A, Godfray, HCJ, Burt, A. Requirements for effective malaria control with homing endonuclease genes. Proc Natl Acad Sci USA. 2011; 108 (43): E874-E880 [OpenAIRE] [PubMed] [DOI]

50 references, page 1 of 4
Abstract
Background The use of gene drive systems to manipulate populations of malaria vectors is currently being investigated as a method of malaria control. One potential system uses driving endonuclease genes (DEGs) to spread genes that impose a genetic load. Previously, models have shown that the introduction of DEG-bearing mosquitoes could suppress or even extinguish vector populations in spatially-heterogeneous environments which were constant over time. In this study, a stochastic spatially-explicit model of mosquito ecology is combined with a rainfall model which enables the generation of a variety of daily precipitation patterns. The model is then used to invest...
Subjects
Medical Subject Headings: parasitic diseasesgenetic structures
free text keywords: Anopheles, Rainfall, Homing endonucleases, Epidemiology, Vector control, Climate-modelling, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Parasitology, Tropical Medicine, Spatial modelling, Weather, ANOPHELES-GAMBIAE, WESTERN KENYA, AQUATIC STAGES, POPULATION, SYSTEM, ELIMINATION, HABITATS, VILLAGE, MODEL, REQUIREMENTS, 1108 Medical Microbiology, Research, Wet season, Atmospheric sciences, Extinction, Gene drive, Dry season, education.field_of_study, education, Virology, Genetic load, Population density, biology.organism_classification, biology
50 references, page 1 of 4

World malaria report 2014. 2014

Global technical strategy for malaria 2016–2030. 2015

Le Menach, A, Takala, S, McKenzie, FE, Perisse, A, Harris, A, Flahault, A. An elaborated feeding cycle model for reductions in vectorial capacity of night-biting mosquitoes by insecticide-treated nets. Malar J. 2007; 6: 10 [OpenAIRE] [PubMed] [DOI]

Ferguson, HM, Dornhaus, A, Beeche, A, Borgemeister, C, Gottlieb, M, Mulla, MS. Ecology: a prerequisite for malaria elimination and eradication. PLoS Med. 2010; 7 (8): e1000303 [OpenAIRE] [PubMed] [DOI]

Read, AF, Lynch, PA, Thomas, MB. How to make evolution-proof insecticides for malaria control. PLoS Biol. 2009; 7 (4): e1000058 [OpenAIRE] [PubMed] [DOI]

Tanner, M, Greenwood, B, Whitty, CJM, Ansah, EK, Price, RN, Dondorp, AM. Malaria eradication and elimination: views on how to translate a vision into reality. BMC Med. 2015; 13: 167 [OpenAIRE] [PubMed] [DOI]

Burt, A. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Biol Sci. 2003; 270: 921-928 [OpenAIRE] [PubMed] [DOI]

Mueller, JE, Bryk, M, Loizos, N, Belfort, M. 4 Homing endonucleases. Cold Spring Harbor Monograph Archive. 1993; 25: 111-143

Hammond, A, Galizi, R, Kyrou, K, Simoni, A, Siniscalchi, C, Katsanos, D. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nat Biotechnol. 2016; 34: 78-83 [OpenAIRE] [PubMed] [DOI]

North, A, Burt, A, Godfray, HCJ. How driving endonuclease genes can be used to combat pests and disease vectors. BMC Biol. 2017; 15: 81 [OpenAIRE] [PubMed] [DOI]

Windbichler, N, Menichelli, M, Papathanos, PA, Thyme, SB, Hui, L, Ulge, UY. A synthetic homing endonuclease-based gene drive system in the human malaria mosquito. Nature. 2011; 473: 212-215 [OpenAIRE] [PubMed] [DOI]

Galizi, R, Doyle, LA, Menichelli, M, Bernardini, F, Deredec, A, Burt, A. A synthetic sex ratio distortion system for the control of the human malaria mosquito. Nat Comm. 2014; 5: 3977 [OpenAIRE] [DOI]

Bernardini, F, Galizi, R, Menichelli, M, Papathanos, PA, Dritsou, V, Marois, E. Site-specific genetic engineering of the Anopheles gambiae Y chromosome. Proc Natl Acad Sci USA. 2014; 111: 7600-7605 [OpenAIRE] [PubMed] [DOI]

Deredec, A, Burt, A, Godfray, HCJ. The population genetics of using homing endonuclease genes in vector and pest management. Genetics. 2008; 179: 2013-2026 [OpenAIRE] [PubMed] [DOI]

Deredec, A, Godfray, HCJ, Burt, A. Requirements for effective malaria control with homing endonuclease genes. Proc Natl Acad Sci USA. 2011; 108 (43): E874-E880 [OpenAIRE] [PubMed] [DOI]

50 references, page 1 of 4
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publication . Other literature type . Article . 2018

The use of driving endonuclease genes to suppress mosquito vectors of malaria in temporally variable environments

Ben Lambert; Ace North; Austin Burt; H. Charles J. Godfray;