publication . Other literature type . Article . 2004

Poor immunogenicity of a self/tumor antigen derives from peptide–MHC-I instability and is independent of tolerance

Tiffany K. Baxter; Nicholas P. Restifo; Zhiya Yu; Brian M. Baker; Christopher E. Touloukian; Lionel Feigenbaum; Scott C. Garman; Marc R. Theoret; Deborah R. Surman;
Open Access
  • Published: 16 Aug 2004
Abstract
Understanding the mechanisms underlying the poor immunogenicity of human self/tumor antigens is challenging because of experimental limitations in humans. Here, we developed a human-mouse chimeric model that allows us to investigate the roles of the frequency and self-reactivity of antigen-specific T cells in determination of the immunogenicity of an epitope (amino acids 209–217) derived from a human melanoma antigen, gp100. In these transgenic mice, CD8 + T cells express the variable regions of a human T cell receptor (hTCR) specific for an HLA-A*0201–restricted gp100209–217. Immunization of hTCR-transgenic mice with gp100209–217 peptide elicited minimal T cell...
Subjects
Medical Subject Headings: chemical and pharmacologic phenomena
free text keywords: Article, General Medicine, CD8, Biology, Immune tolerance, Immune system, Molecular biology, T cell, medicine.anatomical_structure, medicine, Tumor antigen, Epitope, Antigen, Immunogenicity
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