publication . Other literature type . Article . 2012

Depression and Hippocampal Neurogenesis: A Road to Remission?

Eisch, Amelia J.; Petrik, David;
Open Access English
  • Published: 05 Oct 2012
Abstract
<jats:p>Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research—involving stress, depression, and neurogenesis—highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the “neurogenic interactome,” a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives—system, region, and local reg...
Subjects
free text keywords: Article, Multidisciplinary, Mood, Antidepressant, Medicine, business.industry, business, Neuroscience, Hippocampal formation, Hippocampus, Neurogenesis, Interactome, Mood disorders, medicine.disease
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publication . Other literature type . Article . 2012

Depression and Hippocampal Neurogenesis: A Road to Remission?

Eisch, Amelia J.; Petrik, David;