publication . Article . Other literature type . 2017

Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

Qian, Xu; Li, Xinjian; Cai, Qingsong; Zhang, Chuanbao; Yu, Qiujing; Jiang, Yuhui; Lee, Jong-Ho; Hawke, David; Wang, Yugang; Xia, Yan; ...
Open Access
  • Published: 23 Feb 2017 Journal: Molecular Cell, volume 65, pages 917-931,000,000 (issn: 1097-2765, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Summary Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine deprivation and hypoxia result in inhibition of mTOR-mediated acetyl-transferase ARD1 S228 phosphorylation, leading to ARD1-dependent phosphoglycerate kinase 1 (PGK1) K388 acetylation and subsequent PGK1-mediated Beclin1 S30 phosphorylation. This phosphorylation enhances ATG14L-associated class III phosphatidylinositol 3-kinase VPS34 activity by increasing the binding of phosphatidylinositol to VPS34. ARD1-dependent PGK1 acetylation and PGK1-mediated Beclin1 S30 phosphorylation ar...
Subjects
free text keywords: Phosphorylation, Biology, Protein kinase A, Autophagy-related protein 13, Biochemistry, BAG3, Acetylation, Cell biology, Phosphoglycerate kinase 1, education.field_of_study, education, Autophagy, Phosphatidylinositol, chemistry.chemical_compound, chemistry, Article
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