publication . Other literature type . Article . 2013

Insights into the phylogeny and coding potential of microbial dark matter

Jonathan A. Eisen; Stefan M. Sievert; Natalia Ivanova; Jan-Fang Cheng; Alexander Sczyrba; Christian Rinke; Aaron Darling; Brandon Swan; Ramunas Stepanauskas; Jeremy Dodsworth; ...
Open Access
  • Published: 14 Jul 2013
  • Publisher: Springer Science and Business Media LLC
  • Country: Algeria
Abstract
Genome sequencing enhances our understanding of the biological world by providing blueprints for the evolutionary and functional diversity that shapes the biosphere. However, microbial genomes that are currently available are of limited phylogenetic breadth, owing to our historical inability to cultivate most microorganisms in the laboratory. We apply single-cell genomics to target and sequence 201 uncultivated archaeal and bacterial cells fromnine diverse habitats belonging to 29 major mostly uncharted branches of the tree of life, so-called microbial dark matter. With this additional genomic information, we are able to resolve many intra- and inter-phylum-leve...
Subjects
free text keywords: Multidisciplinary
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