publication . Article . Conference object . 2016

Multi-channel multi-distance broadband near-infrared spectroscopy system to measure the spatial response of cellular oxygen metabolism and tissue oxygenation.

David Highton; Martin Smith; Ilias Tachtsidis; Clare E. Elwell; Phong Phan; Jonathan Lai;
Open Access English
  • Published: 05 Oct 2016 Journal: Biomedical Optics Express, volume 7, issue 11, pages 4,424-4,440 (eissn: 2156-7085, Copyright policy)
  • Publisher: Optical Society of America
  • Country: United Kingdom
Abstract
We present a multi-channel, multi-distance broadband near-infrared spectroscopy (NIRS) system with the capability of measuring changes in haemoglobin concentrations (Δ[HbO2], Δ[HHb]), oxidation state of cytochrome-c-oxidase (Δ[oxCCO]) and tissue oxygen saturation (TOI) in the adult human brain. The main components of the instrument are two customized spectrographs and two light sources. Each spectrograph is lens-based to improve light throughput, has a grating enhanced to optimise reflection in the near-infrared (NIR) spectral region and uses a front illuminated cooled CCD camera (−70° C) with a square chip dimension of 12.3 x 12.3 mm (512 x 512 pixels). Each li...
Read more
doi: 10.1364/boe.7.004424
pmc: PMC5119585
pmid: 27895985
Subjects
free text keywords: Article, ocis:(170.6510) Spectroscopy, tissue diagnostics, ocis:(170.3890) Medical optics instrumentation, Biotechnology, Atomic and Molecular Physics, and Optics, Optode, Spectrograph, Absorption spectroscopy, Light intensity, Spectroscopy, Grating, Near-infrared spectroscopy, Materials science, Optics, business.industry, business, Halogen lamp, law.invention, law
Related Organizations
Funded by
RCUK| Multimodal neuroimaging: novel engineering solutions for clinical applications and assistive technologies
Project
Multimodal neuroimaging: novel engineering solutions for clinical applications and assistive technologies
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/K020315/1
  • Funding stream: EPSRC
, WT
Project
  • Funder: Wellcome Trust (WT)
, WT| The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates.
Project
The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates.
  • Funder: Wellcome Trust (WT)
  • Project Code: 088429
  • Funding stream: Neuroscience and Mental Health
, WT| Early bedside biomarkers of cognitive function following neonatal brain injury.
Project
Early bedside biomarkers of cognitive function following neonatal brain injury.
  • Funder: Wellcome Trust (WT)
  • Project Code: 104580
  • Funding stream: Cognitive Neuroscience and Mental Health
Download fromView all 4 versions
Europe PubMed Central
Article . 2016
Provider: PubMed Central
UCL Discovery
Article . 2016
Provider: UCL Discovery
Biomedical Optics Express
Article . 2016
Provider: Crossref
Biomedical Optics Express
Article
Provider: UnpayWall
View more
49 references, page 1 of 4

parameters,” Science 198(4323), 1264-1267 (1977). 6. A. Bainbridge, I. Tachtsidis, S. D. Faulkner, D. Price, T. Zhu, E. Baer, K. D. Broad, D. L. Thomas, E. B. Cady,

Neuroimage 102(Pt 1), 173-183 (2014). 7. S. J. Matcher, C. E. Elwell, C. E. Cooper, M. Cope, and D. T. Delpy, “Performance Comparison of Several

Published Tissue Near-Infrared Spectroscopy Algorithms,” Anal. Biochem. 227(1), 54-68 (1995). 8. C. E. Cooper, M. Cope, R. Springett, P. N. Amess, J. Penrice, L. Tyszczuk, S. Punwani, R. Ordidge, J. Wyatt,

19(1), 27-38 (1999). 9. C. E. Cooper and R. Springett, “Measurement of cytochrome oxidase and mitochondrial energetics by near-

infrared spectroscopy,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 669-676 (1997). 10. K. Uludağ, J. Steinbrink, M. Kohl-Bareis, R. Wenzel, A. Villringer, and H. Obrig, “Cytochrome-c-oxidase

cross talk artefact,” Neuroimage 22(1), 109-119 (2004). 11. G. Bale, C. E. Elwell, and I. Tachtsidis, “From Jöbsis to the present day: a review of clinical near-infrared

spectroscopy measurements of cerebral cytochrome-c-oxidase,” J. Biomed. Opt. 21(9), 091307 (2016). 12. S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, “A tissue oxygenation monitor using NIR spatially

resolved spectroscopy,” Proc. SPIE 3597, 582-592 (1999). 13. P. G. Al-Rawi, P. Smielewski, and P. J. Kirkpatrick, “Evaluation of a near-infrared spectrometer (NIRO 300) for

the detection of intracranial oxygenation changes in the adult head,” Stroke 32(11), 2492-2500 (2001). 14. C. Fedorow and H. P. Grocott, “Cerebral monitoring to optimize outcomes after cardiac surgery,” Curr. Opin.

Anaesthesiol. 23(1), 89-94 (2010). 15. H. A. Vohra, A. Modi, and S. K. Ohri, “Does use of intra-operative cerebral regional oxygen saturation

9(2), 318-322 (2009). 16. C. Kolyva, I. Tachtsidis, A. Ghosh, T. Moroz, C. E. Cooper, M. Smith, and C. E. Elwell, “Systematic

in healthy adults,” Biomed. Opt. Express 3(10), 2550-2566 (2012). 17. J. E. Brazy and D. V. Lewis, “Changes in cerebral blood volume and cytochrome aa3 during hypertensive peaks

in preterm infants,” J. Pediatr. 108(6), 983-987 (1986). 18. J. E. Brazy, D. V. Lewis, M. H. Mitnick, and F. F. Jöbsis vander Vliet, “Noninvasive Monitoring of Cerebral

Oxygenation in Preterm Infants: Preliminary Observations,” Pediatrics 75(2), 217-225 (1985). 19. N. B. Hampson, E. M. Camporesi, B. W. Stolp, R. E. Moon, J. E. Shook, J. A. Griebel, and C. A. Piantadosi,

69(3), 907-913 (1990). 20. J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, and E. O. R. Reynolds, “Quantification of cerebral oxygenation and

49 references, page 1 of 4
Related research
Abstract
We present a multi-channel, multi-distance broadband near-infrared spectroscopy (NIRS) system with the capability of measuring changes in haemoglobin concentrations (Δ[HbO2], Δ[HHb]), oxidation state of cytochrome-c-oxidase (Δ[oxCCO]) and tissue oxygen saturation (TOI) in the adult human brain. The main components of the instrument are two customized spectrographs and two light sources. Each spectrograph is lens-based to improve light throughput, has a grating enhanced to optimise reflection in the near-infrared (NIR) spectral region and uses a front illuminated cooled CCD camera (−70° C) with a square chip dimension of 12.3 x 12.3 mm (512 x 512 pixels). Each li...
Read more
doi: 10.1364/boe.7.004424
pmc: PMC5119585
pmid: 27895985
Subjects
free text keywords: Article, ocis:(170.6510) Spectroscopy, tissue diagnostics, ocis:(170.3890) Medical optics instrumentation, Biotechnology, Atomic and Molecular Physics, and Optics, Optode, Spectrograph, Absorption spectroscopy, Light intensity, Spectroscopy, Grating, Near-infrared spectroscopy, Materials science, Optics, business.industry, business, Halogen lamp, law.invention, law
Related Organizations
Funded by
RCUK| Multimodal neuroimaging: novel engineering solutions for clinical applications and assistive technologies
Project
Multimodal neuroimaging: novel engineering solutions for clinical applications and assistive technologies
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/K020315/1
  • Funding stream: EPSRC
, WT
Project
  • Funder: Wellcome Trust (WT)
, WT| The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates.
Project
The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates.
  • Funder: Wellcome Trust (WT)
  • Project Code: 088429
  • Funding stream: Neuroscience and Mental Health
, WT| Early bedside biomarkers of cognitive function following neonatal brain injury.
Project
Early bedside biomarkers of cognitive function following neonatal brain injury.
  • Funder: Wellcome Trust (WT)
  • Project Code: 104580
  • Funding stream: Cognitive Neuroscience and Mental Health
Download fromView all 4 versions
Europe PubMed Central
Article . 2016
Provider: PubMed Central
UCL Discovery
Article . 2016
Provider: UCL Discovery
Biomedical Optics Express
Article . 2016
Provider: Crossref
Biomedical Optics Express
Article
Provider: UnpayWall
View more
49 references, page 1 of 4

parameters,” Science 198(4323), 1264-1267 (1977). 6. A. Bainbridge, I. Tachtsidis, S. D. Faulkner, D. Price, T. Zhu, E. Baer, K. D. Broad, D. L. Thomas, E. B. Cady,

Neuroimage 102(Pt 1), 173-183 (2014). 7. S. J. Matcher, C. E. Elwell, C. E. Cooper, M. Cope, and D. T. Delpy, “Performance Comparison of Several

Published Tissue Near-Infrared Spectroscopy Algorithms,” Anal. Biochem. 227(1), 54-68 (1995). 8. C. E. Cooper, M. Cope, R. Springett, P. N. Amess, J. Penrice, L. Tyszczuk, S. Punwani, R. Ordidge, J. Wyatt,

19(1), 27-38 (1999). 9. C. E. Cooper and R. Springett, “Measurement of cytochrome oxidase and mitochondrial energetics by near-

infrared spectroscopy,” Philos. Trans. R. Soc. Lond. B Biol. Sci. 352(1354), 669-676 (1997). 10. K. Uludağ, J. Steinbrink, M. Kohl-Bareis, R. Wenzel, A. Villringer, and H. Obrig, “Cytochrome-c-oxidase

cross talk artefact,” Neuroimage 22(1), 109-119 (2004). 11. G. Bale, C. E. Elwell, and I. Tachtsidis, “From Jöbsis to the present day: a review of clinical near-infrared

spectroscopy measurements of cerebral cytochrome-c-oxidase,” J. Biomed. Opt. 21(9), 091307 (2016). 12. S. Suzuki, S. Takasaki, T. Ozaki, and Y. Kobayashi, “A tissue oxygenation monitor using NIR spatially

resolved spectroscopy,” Proc. SPIE 3597, 582-592 (1999). 13. P. G. Al-Rawi, P. Smielewski, and P. J. Kirkpatrick, “Evaluation of a near-infrared spectrometer (NIRO 300) for

the detection of intracranial oxygenation changes in the adult head,” Stroke 32(11), 2492-2500 (2001). 14. C. Fedorow and H. P. Grocott, “Cerebral monitoring to optimize outcomes after cardiac surgery,” Curr. Opin.

Anaesthesiol. 23(1), 89-94 (2010). 15. H. A. Vohra, A. Modi, and S. K. Ohri, “Does use of intra-operative cerebral regional oxygen saturation

9(2), 318-322 (2009). 16. C. Kolyva, I. Tachtsidis, A. Ghosh, T. Moroz, C. E. Cooper, M. Smith, and C. E. Elwell, “Systematic

in healthy adults,” Biomed. Opt. Express 3(10), 2550-2566 (2012). 17. J. E. Brazy and D. V. Lewis, “Changes in cerebral blood volume and cytochrome aa3 during hypertensive peaks

in preterm infants,” J. Pediatr. 108(6), 983-987 (1986). 18. J. E. Brazy, D. V. Lewis, M. H. Mitnick, and F. F. Jöbsis vander Vliet, “Noninvasive Monitoring of Cerebral

Oxygenation in Preterm Infants: Preliminary Observations,” Pediatrics 75(2), 217-225 (1985). 19. N. B. Hampson, E. M. Camporesi, B. W. Stolp, R. E. Moon, J. E. Shook, J. A. Griebel, and C. A. Piantadosi,

69(3), 907-913 (1990). 20. J. S. Wyatt, M. Cope, D. T. Delpy, S. Wray, and E. O. R. Reynolds, “Quantification of cerebral oxygenation and

49 references, page 1 of 4
Related research
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue