publication . Other literature type . Article . 2015

Morphometric correlates of dysarthric deficit in amyotrophic lateral sclerosis

Matteo De Marco; Antonio Merico; Giulia Berta; Nicoletta Segato; Valentina Citton; Alessandro Baglione; Annalena Venneri;
  • Published: 29 Jun 2015
  • Publisher: Informa UK Limited
  • Country: United Kingdom
Abstract
Our objective was to investigate the volumetric correlates of speech in amyotrophic lateral sclerosis (ALS). Twenty-three ALS patients had a structural 3D MRI scan, neuropsychological, linguistic and speech assessments. Twenty-three healthy adults of comparable age, education, white-matter hyperintensity load and intracranial volumes were also recruited. Between-group differences in grey matter and white matter (WM) were examined to characterize ALS patients accurately. The association between residual speech and volumetric maps was studied in these patients. Results demonstrated that ALS patients showed a pattern of WM reduction, which was located in peri-corti...
Subjects
free text keywords: Dysarthria, medicine.symptom, medicine, Grey matter, medicine.anatomical_structure, Amyotrophic lateral sclerosis, medicine.disease, White matter, Neuropsychology, Hyperintensity, Voxel-based morphometry, Audiology, medicine.medical_specialty, Pons, business.industry, business
46 references, page 1 of 4

1- Kollewe K, Körner S, Dengler R, Petri S, Mohammadi B. Magnetic resonance imaging in amyotrophic lateral sclerosis. Neurol Res Int 2012;2012:608501. [OpenAIRE]

2- Tsermentseli S, Leigh PN, Goldstein LH. The anatomy of cognitive impairment in amyotrophic lateral sclerosis: More than frontal lobe dysfunction. Cortex 2012;48:166-182. [OpenAIRE]

3- Consonni M, Iannaccone S, Cerami C, Frasson P, Lacerenza M, Lunetta C, et al. The cognitive and behavioural profile of amyotrophic lateral sclerosis: Application of the consensus criteria. Behav Neurol 2013;27:143-153. [OpenAIRE]

4- Oh S, Park A, Kim HJ, Oh KW, Choi H, Kwon MJ, et al. Spectrum of cognitive impairment in Korean ALS patients without known genetic mutations. PLoS One 2014;e87163.

5- Taylor LJ, Brown RG, Tsermentseli S, Al-Chalabi A, Shaw CE, Ellis CM, et al. Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis? J Neurol Neurosurg Psychiatry 2013;84:494-498.

6- Bede P, Bokde AL, Byrne S, Elamin M, McLaughlin RL, Kenna K, et al. Multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology 2013;81(4):361-369.

7- Tomik B, Guiloff RJ. Dysarthria in amyotrophic lateral sclerosis: A review. Amyotroph Lateral Scler 2010;11:4-15.

8- Bak TH, Hodges JR. Motor neurone disease, dementia and aphasia: coincidence, cooccurrence or continuum? J Neurol 2001;248:260-270.

9- Wilkinson C, Yorkston KM, Strand EA, Rogers M. Features of spontaneous language in speakers with amyotrophic lateral sclerosis and dysarthria. Am J Speech Lang Pathol 1995;4(4):139-142.

10- Kent RD, Kent JF, Weismer G, Duffy JR. What dysarthrias can tell us about the neural control of speech. J Phon 2000;28:273-302.

11- Bede P, Bokde A, Elamin M, Byrne S, McLaughlin RL, Jordan N, et al. Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. J Neurol Neurosurg Psychiatry 2013;84(7):766-773.

12- Walhout R, Westeneng HJ, Verstraete E, Hendrikse J, Veldink JH, van den Heuvel MP, et al. Cortical thickness in ALS: Towards a marker for upper motor involvement. J Neurol Neurosurg Psychiatry 2015;86(3):288-294.

13- Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 1999;169:13-21. [OpenAIRE]

14- Brooks BR, Miller RG, Swash M, Munsat TL, for the World Federation of Neurology Research Group on Motor Neuron Disease. El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2000;1(5):293-299.

15- Keith RA, Granger CV, Hamilton BB, Sherwin FS. The functional independence measure: a new tool for rehabilitation. Adv Clin Rehabil 1987;1:6-18.

46 references, page 1 of 4
Abstract
Our objective was to investigate the volumetric correlates of speech in amyotrophic lateral sclerosis (ALS). Twenty-three ALS patients had a structural 3D MRI scan, neuropsychological, linguistic and speech assessments. Twenty-three healthy adults of comparable age, education, white-matter hyperintensity load and intracranial volumes were also recruited. Between-group differences in grey matter and white matter (WM) were examined to characterize ALS patients accurately. The association between residual speech and volumetric maps was studied in these patients. Results demonstrated that ALS patients showed a pattern of WM reduction, which was located in peri-corti...
Subjects
free text keywords: Dysarthria, medicine.symptom, medicine, Grey matter, medicine.anatomical_structure, Amyotrophic lateral sclerosis, medicine.disease, White matter, Neuropsychology, Hyperintensity, Voxel-based morphometry, Audiology, medicine.medical_specialty, Pons, business.industry, business
46 references, page 1 of 4

1- Kollewe K, Körner S, Dengler R, Petri S, Mohammadi B. Magnetic resonance imaging in amyotrophic lateral sclerosis. Neurol Res Int 2012;2012:608501. [OpenAIRE]

2- Tsermentseli S, Leigh PN, Goldstein LH. The anatomy of cognitive impairment in amyotrophic lateral sclerosis: More than frontal lobe dysfunction. Cortex 2012;48:166-182. [OpenAIRE]

3- Consonni M, Iannaccone S, Cerami C, Frasson P, Lacerenza M, Lunetta C, et al. The cognitive and behavioural profile of amyotrophic lateral sclerosis: Application of the consensus criteria. Behav Neurol 2013;27:143-153. [OpenAIRE]

4- Oh S, Park A, Kim HJ, Oh KW, Choi H, Kwon MJ, et al. Spectrum of cognitive impairment in Korean ALS patients without known genetic mutations. PLoS One 2014;e87163.

5- Taylor LJ, Brown RG, Tsermentseli S, Al-Chalabi A, Shaw CE, Ellis CM, et al. Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis? J Neurol Neurosurg Psychiatry 2013;84:494-498.

6- Bede P, Bokde AL, Byrne S, Elamin M, McLaughlin RL, Kenna K, et al. Multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology 2013;81(4):361-369.

7- Tomik B, Guiloff RJ. Dysarthria in amyotrophic lateral sclerosis: A review. Amyotroph Lateral Scler 2010;11:4-15.

8- Bak TH, Hodges JR. Motor neurone disease, dementia and aphasia: coincidence, cooccurrence or continuum? J Neurol 2001;248:260-270.

9- Wilkinson C, Yorkston KM, Strand EA, Rogers M. Features of spontaneous language in speakers with amyotrophic lateral sclerosis and dysarthria. Am J Speech Lang Pathol 1995;4(4):139-142.

10- Kent RD, Kent JF, Weismer G, Duffy JR. What dysarthrias can tell us about the neural control of speech. J Phon 2000;28:273-302.

11- Bede P, Bokde A, Elamin M, Byrne S, McLaughlin RL, Jordan N, et al. Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. J Neurol Neurosurg Psychiatry 2013;84(7):766-773.

12- Walhout R, Westeneng HJ, Verstraete E, Hendrikse J, Veldink JH, van den Heuvel MP, et al. Cortical thickness in ALS: Towards a marker for upper motor involvement. J Neurol Neurosurg Psychiatry 2015;86(3):288-294.

13- Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 1999;169:13-21. [OpenAIRE]

14- Brooks BR, Miller RG, Swash M, Munsat TL, for the World Federation of Neurology Research Group on Motor Neuron Disease. El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2000;1(5):293-299.

15- Keith RA, Granger CV, Hamilton BB, Sherwin FS. The functional independence measure: a new tool for rehabilitation. Adv Clin Rehabil 1987;1:6-18.

46 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2015

Morphometric correlates of dysarthric deficit in amyotrophic lateral sclerosis

Matteo De Marco; Antonio Merico; Giulia Berta; Nicoletta Segato; Valentina Citton; Alessandro Baglione; Annalena Venneri;