publication . Other literature type . Article . 1998

Basic Fibroblast Growth Factor: A Missing Link between Collagen VII, Increased Collagenase, and Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa

Arbiser, J. L.; Fine, J. -D; Murrell, D.; Amy Paller; Connors, S.; Keough, K.; Marsh, E.; Folkman, J.;
Open Access English
  • Published: 01 Mar 1998
  • Publisher: The Feinstein Institute for Medical Research
Abstract
BACKGROUND: Patients with recessive dystrophic epidermolysis bullosa (RDEB) have deficiencies of collagen type VII and have elevated levels of fibroblast collagenase, and a greatly increased risk of cutaneous squamous cell carcinoma. Patients with other genetic blistering disorders do not have elevated collagenase or an increased risk of squamous cell carcinoma, despite chronic wounding. The connection between collagen type VII deficiency, increased collagenase, and squamous cell carcinoma is not understood. MATERIALS AND METHODS: Urine from 81 patients with RDEB (39 patients), junctional epidermolysis bullosa (JEB; 12 patients), and epidermolysis bullosa simple...
Subjects
free text keywords: Research Article, Genetics(clinical), Molecular Medicine, Genetics, Molecular Biology, Basic fibroblast growth factor, chemistry.chemical_compound, chemistry, Collagenase, medicine.drug, medicine, Fibroblast, medicine.anatomical_structure, Cell, Epidermolysis bullosa dystrophica, medicine.disease, Carcinoma, Epidermolysis bullosa simplex, Biology, Immunology, Pathology, medicine.medical_specialty
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